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1. (WO1994026276) TRICYCLOPOLYAZAMACROCYCLOPHOSPHONIC ACIDS, COMPLEXES AND DERIVATIVES THEREOF, FOR USE AS CONTRAST AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/026276    International Application No.:    PCT/US1994/005071
Publication Date: 24.11.1994 International Filing Date: 06.05.1994
Chapter 2 Demand Filed:    02.12.1994    
IPC:
C07D 471/18 (2006.01), C07D 471/22 (2006.01), C07F 9/6561 (2006.01), G01R 33/28 (2006.01)
Applicants: THE DOW CHEMICAL COMPANY [US/US]; 2030 Dow Center, Abbott Road, Midland, MI 48640 (US)
Inventors: KIEFER, Garry, E.; (US)
Agent: KIMBLE, Karen, L.; The Dow Chemical Company, Patent Department, P.O. Box 1967, Midland, MI 48641-1967 (US)
Priority Data:
058,622 06.05.1993 US
Title (EN) TRICYCLOPOLYAZAMACROCYCLOPHOSPHONIC ACIDS, COMPLEXES AND DERIVATIVES THEREOF, FOR USE AS CONTRAST AGENTS
(FR) ACIDES TRICYCLOPOLYAZAMACROCYCLOPHOSPHONIQUES, LEURS COMPLEXES ET LEURS DERIVES, POUR UNE UTILISATION EN TANT QU'AGENTS DE CONTRASTE
Abstract: front page image
(EN)Tri- and tetra-cyclopolyazamacrocyclophosphonic acid compounds and their derivatives are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the $i(in vivo) biolocalization. The complexes are useful as contrast agents for diagnostic purposes.
(FR)On décrit des acides tri- et tétracyclopolyazamacrocyclophosphoniques et leurs dérivés, qui peuvent former des complexes inertes avec les ions Gd, Mn ou Fe. La charge globale des complexes peut être changée pour modifier leur localisation $i(in vivo). Les complexes sont utiles comme agents de contraste pour effectuer des diagnostics.
Designated States: AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, ES, FI, GB, HU, JP, KR, KZ, LK, LU, LV, MG, MN, MW, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SI, SK, UA, UZ, VN.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)