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1. (WO1994025485) OXYTOCIN ANTAGONIST
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/025485    International Application No.:    PCT/US1994/001439
Publication Date: 10.11.1994 International Filing Date: 09.02.1994
Chapter 2 Demand Filed:    14.11.1994    
IPC:
A61K 38/00 (2006.01), C07K 7/16 (2006.01)
Applicants: NORTHWESTERN UNIVERSITY [US/US]; 633 Clark Street, Evanston, IL 60208 (US)
Inventors: FLOURET, George; (US).
WILSON, Laird; (US)
Agent: TILTON, Timothy, L.; Tilton, Fallon, Lungmus & Chestnut, 100 South Wacker Dr., Suite 960, Chicago, IL 60606 (US)
Priority Data:
08/052,887 26.04.1993 US
Title (EN) OXYTOCIN ANTAGONIST
(FR) ANTAGONISTE DE L'OXYTOCINE
Abstract: front page image
(EN)The oxytocin antagonist represented by formula (I) wherein (S-Pmp IS $g(b),$g(b)-(3-thiapentamethylene)-$g(b)-mercaptopropionic acid, D-Trp is the D form of tryptophan, and Ile, Gln, Asn, Pen (Pen = penicillamine), Pro, and Arg are the L forms of isoleucine, glutamine, asparagine, proline and arginine, respectively. This compound can be administered to pregnant women to arrest premature labor while avoiding unwanted side effects due to antagonism of the antidiuretic hormone, vasopressin.
(FR)Un antagoniste de l'oxytocine est représenté par la formule (I) où (S)Pmp désigne l'acide $g(b),$g(b)-(3-thiapentaméthylène)-$g(b)-mercaptoproprionique, D-Trp est la forme D de tryptophane, et Ile, Gln, Asn, Pen (Pen = penicillamine), Pro, and Arg sont les formes L respectivement d'isoleucine, de glutamine, d'asparagine, de proline et d'arginine. On peut administrer ce composé à des femmes enceintes afin d'arrêter l'accouchement prématuré, tout en évitant des effets secondaires indésirables dûs à l'antagonisme vis-à-vis de l'hormone anti-diurétique vasopressine.
Designated States: AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, ES, FI, GB, HU, JP, KP, KR, KZ, LK, LU, LV, MG, MN, MW, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SK, UA, UZ, VN.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)