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Machine translation
1. (WO1994025449) OXIDATION PRODUCTS OF CEPHALOMANNINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/025449    International Application No.:    PCT/US1994/004519
Publication Date: 10.11.1994 International Filing Date: 25.04.1994
Chapter 2 Demand Filed:    23.11.1994    
IPC:
C07D 305/14 (2006.01), C07D 413/12 (2006.01)
Applicants: HAUSER CHEMICAL RESEARCH, INC. [US/US]; 5555 Airport Boulevard, Boulder, CO 80301 (US)
Inventors: MURRAY, Christopher, K.; (US).
BECKVERMIT, Jeffrey, T.; (US).
ZIEBARTH, Timothy, D.; (US)
Agent: EDMUNDSON, Dean, P.; Suite 2160, 1136 East Stuart Street, Fort Collins, CO 80525 (US).
LADAS & PARRY; Altheimer Eck 2, D-80331 Munich 2 (DE)
Priority Data:
08/053,902 26.04.1993 US
Title (EN) OXIDATION PRODUCTS OF CEPHALOMANNINE
(FR) PRODUITS D'OXYDATION DE CEPHALOMANNINE
Abstract: front page image
(EN)Antineoplastic taxol derivatives are derived by selective oxidation of the alkene portion of the side chain of cephalomannine. The derivative displays high activity in promoting assembly of microtubulin and also displays cytotoxic activity against malignant cells.
(FR)On prépare des dérivés antinéoplasiques de taxol par oxydation sélective de la partie alkène de la chaîne latérale de céphalomannine. Le dérivé présente une efficacité importante dans la promotion de l'assemblage de la microtubuline, ainsi qu'une efficacité cytotoxique contre des cellules malignes.
Designated States: AU, CA, JP.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)