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Machine translation
1. (WO1994025431) CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING N(3-BIPHENYLYL-1(S)-METHYL-2-PROPENYL) ACETOHYDROXAMIC ACID DERIVATIVES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/025431    International Application No.:    PCT/GB1994/000886
Publication Date: 10.11.1994 International Filing Date: 26.04.1994
Chapter 2 Demand Filed:    16.08.1994    
IPC:
C07C 17/263 (2006.01), C07C 33/28 (2006.01), C07C 45/00 (2006.01), C07C 45/72 (2006.01), C07C 49/235 (2006.01), C07C 255/53 (2006.01), C07C 255/56 (2006.01), C07C 259/06 (2006.01), C07C 271/00 (2006.01), C07C 275/64 (2006.01)
Applicants: THE WELLCOME FOUNDATION LIMITED [GB/GB]; Unicorn House, 160 Euston Road, London NW1 2BP (GB) (For All Designated States Except US).
HODGSON, Simon, Teanby [GB/GB]; (GB) (For US Only).
WATES, Peter, John [GB/GB]; (GB) (For US Only)
Inventors: HODGSON, Simon, Teanby; (GB).
WATES, Peter, John; (GB)
Agent: ROLLINS, Anthony, John; The Wellcome Foundation Limited, Langley Court, Beckenham, Kent BR3 3BS (GB)
Priority Data:
9308652.8 27.04.1993 GB
9318432.3 06.09.1993 GB
Title (EN) CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING N(3-BIPHENYLYL-1(S)-METHYL-2-PROPENYL) ACETOHYDROXAMIC ACID DERIVATIVES
(FR) DERIVES DE L'ACIDE ACETOHYDROXAMIQUE N (3-BIPHENYLYL-1(S)-METHYL-2-PROPENYL) INHIBITEURS DE LA CYCLOOXYGENASE ET DE LA 5-LIPOXYGENASE
Abstract: front page image
(EN)The present invention is concerned with novel hydroxamic acid derivatives of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of clinical conditions for which an inhibitor of the lipoxygenase or cyclooxygenase mediated arachidonic acid metabolic pathway is indicated. The invention also relates to pharmaceutical formulations and processes for the preparation of compounds according to the invention. In formula (I), X is cyano, fluoro, or chloro; or a salt, solvate, or physiologically functional derivative thereof.
(FR)L'invention porte sur de nouveaux dérivés de l'acide hydroxamique de formule (I), et sur leur utilisation thérapeutique, particulièrement pour la prophylaxie ou le traitement d'états cliniques pour lesquels est indiqué un inhibiteur de la voie métabolique de l'acide arachidonique à médiation cyclooxygénasique et lipoxygénasique. L'invention porte également sur des formulations pharmaceutiques et des procédés de préparation de composés relevant de l'invention. Dans la formule (I), X est un cyano, un fluoro, ou un chloro. Sont également décrits un sel, un solvate, ou un dérivé physiologiquement fonctionnel de ces composés.
Designated States: AU, CA, CN, CZ, FI, GE, HU, JP, KR, KZ, NO, NZ, PL, RU, SI, SK, UA, US, UZ.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)