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Machine translation
1. (WO1994025429) 4-AMINO-FLUOROBENZAMIDES AND THEIR USE AS CYTOTOXIC PRODRUGS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/025429    International Application No.:    PCT/GB1994/000941
Publication Date: 10.11.1994 International Filing Date: 03.05.1994
Chapter 2 Demand Filed:    28.11.1994    
IPC:
A61K 47/48 (2006.01), C07C 229/60 (2006.01), C07C 237/36 (2006.01)
Applicants: CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED [GB/GB]; Cambridge House, 6-10 Cambridge Terrace, Regent's Park, London NW1 4JL (GB) (For All Designated States Except US).
SPRINGER, Caroline, Joy [GB/GB]; (GB) (For US Only)
Inventors: SPRINGER, Caroline, Joy; (GB)
Agent: BRASNETT, Adrian, Hugh; J.A. Kemp & Co., 14 South Square, Gray's Inn, London WC1R 5LX (GB)
Priority Data:
9308957.1 30.04.1993 GB
Title (EN) 4-AMINO-FLUOROBENZAMIDES AND THEIR USE AS CYTOTOXIC PRODRUGS
(FR) 4-AMINO-FLUOROBENZAMIDES ET LEUR UTILISATION COMME PROMEDICAMENTS CYTOTOXIQUES
Abstract: front page image
(EN)The invention provides a compound which is a 3-fluorobenzamide of formula (A) wherein R-NH is the residue of an $g(a)-amino acid R-NH¿2? or oligopeptide R-NH¿2?, and M is a nitrogen mustard group of formula (A') wherein Y and L, which may be the same or differnt in a molecule, are leaving groups; or a pharmaceutically acceptable salt thereof. The compounds are useful as prodrugs for treating cancer.
(FR)L'invention concerne un composé de 3-fluorobenzamide de formule (A) dans laquelle R-NH est un résidu d'un $g(a)-aminoacide R-NH¿2? ou un oligopeptide R-NH¿2?, et M est un groupe moutarde à l'azote de formule (A') dans laquelle Y et L qui peuvent être identiques ou différents dans une molécule, sont des groupes sortants. L'invention concerne également un sel pharmaceutiquement acceptable desdits composés, ces derniers étant utilisés comme promédicaments pour le traitement du cancer.
Designated States: JP, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)