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Machine translation
1. (WO1994025051) THROMBIN INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/025051    International Application No.:    PCT/US1994/004539
Publication Date: 10.11.1994 International Filing Date: 25.04.1994
Chapter 2 Demand Filed:    14.11.1994    
IPC:
A61K 38/00 (2006.01), C07K 5/02 (2006.01), C07K 5/06 (2006.01), C07K 5/065 (2006.01), C07K 5/087 (2006.01)
Applicants: MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue, Rahway, NJ 07065 (US) (For All Designated States Except US).
VEBER, Daniel, F. [US/US]; (US) (For US Only).
LEWIS, S., Dale [US/US]; (US) (For US Only).
SHAFER, Jules, A. [US/US]; (US) (For US Only).
FENG, Dong-Mei [CN/US]; (US) (For US Only).
NUTT, Ruth, F. [US/US]; (US) (For US Only).
BRADY, Stephen, F. [US/US]; (US) (For US Only)
Inventors: VEBER, Daniel, F.; (US).
LEWIS, S., Dale; (US).
SHAFER, Jules, A.; (US).
FENG, Dong-Mei; (US).
NUTT, Ruth, F.; (US).
BRADY, Stephen, F.; (US)
Agent: MERCK & CO., INC.; Patent Dept., 126 East Lincoln Avenue, Rahway, NJ 07065 (US)
Priority Data:
055,611 30.04.1993 US
Title (EN) THROMBIN INHIBITORS
(FR) INHIBITEURS DE THROMBINE
Abstract: front page image
(EN)4-substituted cyclohexylamine derivatives which are thrombin catalytic site inhibitors and which are useful as anticoagulants. These compounds show selectivity for thrombin over other trypsin-like enzymes and have oral bioavailability. They have formula (a) or (b), for example (c).
(FR)Dérivés de cyclohexylamine substitués en position 4, agissant comme inhibiteurs de site catalytique de thrombine et aptes à être utilisés comme anticoagulants. Ces composés présentent une plus grande sélectivité pour la thrombine que pour les autres enzymes de type trypsine, ainsi qu'une biodisponibilité orale. Ils répondent à la formule (a) ou (b), par exemple (c).
Designated States: AU, BB, BG, BR, BY, CA, CN, CZ, FI, HU, JP, KR, KZ, LK, LV, MG, MN, MW, NO, NZ, PL, RO, RU, SD, SI, SK, TT, UA, US, UZ.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)