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1. (WO1994020062) BALANOIDS AS PROTEIN KINASE C INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1994/020062 International Application No.: PCT/US1994/002283
Publication Date: 15.09.1994 International Filing Date: 02.03.1994
Chapter 2 Demand Filed: 19.09.1994
IPC:
C07C 235/54 (2006.01) ,C07C 255/52 (2006.01) ,C07C 311/09 (2006.01) ,C07D 207/14 (2006.01) ,C07D 207/48 (2006.01) ,C07D 211/56 (2006.01) ,C07D 223/12 (2006.01) ,C07D 257/04 (2006.01) ,C07D 313/04 (2006.01) ,C07D 337/04 (2006.01) ,C07D 401/12 (2006.01) ,C07D 417/12 (2006.01) ,C07F 9/572 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
42
having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
44
with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
54
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
255
Carboxylic acid nitriles
49
having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
52
to carbon atoms of six-membered aromatic rings being part of condensed ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
311
Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
01
Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
02
of an acyclic saturated carbon skeleton
09
the carbon skeleton being further substituted by at least two halogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
04
having no double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
14
Nitrogen atoms not forming part of a nitro radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
46
with hetero atoms directly attached to the ring nitrogen atom
48
Sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
36
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56
Nitrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
223
Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
02
not condensed with other rings
06
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
12
Nitrogen atoms not forming part of a nitro radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
257
Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02
not condensed with other rings
04
Five-membered rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
313
Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
02
Seven-membered rings
04
not condensed with other rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
337
Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
02
Seven-membered rings
04
not condensed with other rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
547
Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
553
having one nitrogen atom as the only ring hetero atom
572
Five-membered rings
Applicants:
HALL, Steven, Edward [US/US]; US (UsOnly)
BALLAS, Lawrence, M. [US/US]; US (UsOnly)
KULANTHAIVEL, Palaniappan [IN/US]; US (UsOnly)
BOROS, Christie [US/US]; US (UsOnly)
JIANG, Jack, B. [US/US]; US (UsOnly)
JAGDMANN, Gunnar, Erik, Jr. [US/US]; US (UsOnly)
LAI, Yen-Shi [--/US]; US (UsOnly)
BIGGERS, Christopher, K. [US/US]; US (UsOnly)
HU, Hong [CN/US]; US (UsOnly)
HALLOCK, Yali [CN/US]; US (UsOnly)
HUGHES, Philip, F. [US/US]; US (UsOnly)
DEFAUW, Jean, Marie [US/US]; US (UsOnly)
LYNCH, Michael, Patrick [US/US]; US (UsOnly)
LAMPE, John, William, Crossley [US/US]; US (UsOnly)
MENALDINO, David, Steven [US/US]; US (UsOnly)
HEERDING, Julia, Marie [US/US]; US (UsOnly)
JANZEN, William, P. [US/US]; US (UsOnly)
HOLLINSHEAD, Sean, Patrick [GB/US]; US (UsOnly)
ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center Indianapolis, IN 46285, US (AllExceptUS)
NICHOLS, Gina, M. [US/US]; US (UsOnly)
Inventors:
HALL, Steven, Edward; US
BALLAS, Lawrence, M.; US
KULANTHAIVEL, Palaniappan; US
BOROS, Christie; US
JIANG, Jack, B.; US
JAGDMANN, Gunnar, Erik, Jr.; US
LAI, Yen-Shi; US
BIGGERS, Christopher, K.; US
HU, Hong; US
HALLOCK, Yali; US
HUGHES, Philip, F.; US
DEFAUW, Jean, Marie; US
LYNCH, Michael, Patrick; US
LAMPE, John, William, Crossley; US
MENALDINO, David, Steven; US
HEERDING, Julia, Marie; US
JANZEN, William, P.; US
HOLLINSHEAD, Sean, Patrick; US
NICHOLS, Jeffrey, Bailey; null
Agent:
BENJAMIN, Roger, S.; Eli Lilly and Company Lilly Corporate Center Indianapolis, IN 46285, US
Priority Data:
08/025,84603.03.1993US
Title (EN) BALANOIDS AS PROTEIN KINASE C INHIBITORS
(FR) BALANOIDES UTILISABLES COMME INHIBITEURS DE LA PROTEINE KINASE C
Abstract:
(EN) A novel class of therapeutic compounds, denominated Balanoids, is disclosed. Balanoids have protein kinase C inhibitory activity and selectivity among the isoforms of protein kinase C. Balanoids are useful for treatment of diseases related to protein kinase C in animals, especially humans and is especially indicated for treatment of inflammatory diseases.
(FR) Nouvelle classe de composés thérapeutiques nommés balanoïdes. Lesdits composés possèdent une activité inhibitrice de la protéine kinase C et une sélectivité parmi les isoformes de la protéine kinase C. Les balanoïdes sont utiles pour traiter les maladies liées à la protéine kinase C chez les animaux, en particulier chez leshumains, et ils sont particulièrement indiqués pour traiter les maladies inflammatoires.
Designated States: AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, ES, FI, GB, HU, JP, KP, KR, KZ, LK, LU, LV, MG, MN, MW, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SK, UA, US, UZ, VN
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)