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Machine translation
1. (WO1994016332) METHOD FOR SCREENING CATALYTIC NON-ENZYME POLYPEPTIDES AND PROTEINS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/016332    International Application No.:    PCT/US1994/000424
Publication Date: 21.07.1994 International Filing Date: 12.01.1994
Chapter 2 Demand Filed:    09.08.1994    
IPC:
G01N 33/573 (2006.01), G01N 33/68 (2006.01)
Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD. [IL/IL]; P.O. Box 95, 76100 Rehovot (IL) (For All Designated States Except US).
YISSUM RESEARCH AND DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM [IL/IL]; 46 Jabotinsky Street, 91999 Jerusalem (IL) (For All Designated States Except US).
ESHHAR, Zelig [IL/IL]; (IL) (For US Only).
GREEN, Bernard, S. [US/IL]; (IL) (For US Only).
TAWFIK, Dan, S. [IL/IL]; (IL) (For US Only)
Inventors: ESHHAR, Zelig; (IL).
GREEN, Bernard, S.; (IL).
TAWFIK, Dan, S.; (IL)
Agent: LATKER, Norman, J.; Browdy & Neimark, 419 7th Street N.W., Suite 300, Washington, DC 20004 (US)
Priority Data:
104384 13.01.1993 IL
Title (EN) METHOD FOR SCREENING CATALYTIC NON-ENZYME POLYPEPTIDES AND PROTEINS
(FR) PROCEDE DE CRIBLAGE DE POLYPEPTIDES ET DE PROTEINES NON ENZYMATIQUES CATALYTIQUES
Abstract: front page image
(EN)A method for screening or detection of a non-enzyme catalytic polypeptide or protein for the conversion of a substrate S to a product P is provided, in which a preparation containing the potential catalyst is contacted with the substrate S immobilized to a support and the immobilized product P obtained is detected, preferably by immunoassay. The method is preferably used for the screening of hybridoma supernatants for catalytic monoclonal antibodies that catalyze acyl transfer reactions, e.g., hydrolysis or aminolysis, condensation reactions and resolution of enantiomers.
(FR)L'invention se rapporte à un procédé de criblage ou de détection d'un polypeptide ou d'une protéine catalytique non enzymatique servant à transformer un substrat S en un produit P. Une préparation contenant le catalyseur potentiel est mise en contact avec le substrat S immobilisé sur un support et le produit P immobilisé obtenu est détecté, de préférence, par dosage immunologique. Le procédé est de préférence utilisé dans le criblage de surnageants d'hybridome pour des anticorps monoclonaux catalytiques qui catalysent les réactions de transfert d'acyle, par exemple, l'hydrolyse ou l'aminolyse, les réactions de condensation et la résolution d'énantiomères.
Designated States: CA, JP, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)