WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO1994015925) MANGANESE COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/015925    International Application No.:    PCT/US1994/000169
Publication Date: 21.07.1994 International Filing Date: 05.01.1994
Chapter 2 Demand Filed:    09.08.1994    
IPC:
A61K 31/555 (2006.01), C07D 259/00 (2006.01), C07F 13/00 (2006.01)
Applicants: MONSANTO COMPANY [US/US]; 800 North Lindbergh Boulevard, St. Louis, MO 63167 (US)
Inventors: ASTON, Karl, William; (US).
LENNON, Patrick, James; (US).
MODAK, Anil, Shrikrishna; (US).
NEUMANN, William, Lojda; (US).
RILEY, Dennis, Patrick; (US).
WEISS, Randy, Herman; (US)
Agent: BOLDING, James, Clifton; Monsanto Company, 800 North Lindbergh Boulevard, St. Louis, MO 63167 (US).
ERNST, Hubert, G.; Monsanto Services International, Patent Department, 270/272, avenue de Tervuren, B-1150 Brussels (BE)
Priority Data:
004,444 14.01.1993 US
Title (EN) MANGANESE COMPLEXES OF NITROGEN-CONTAINING MACROCYCLIC LIGANDS EFFECTIVE AS CATALYSTS FOR DISMUTATING SUPEROXIDE
(FR) COMPLEXES MANGANESIENS DE LIGANDS MACROCYCLIQUES CONTENANT DE L'AZOTE ET EFFICACES COMME CATALYSEURS POUR LA DISMUTATION DU SUPEROXYDE
Abstract: front page image
(EN)The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by formula (I), wherein R, R', R¿1?, R'¿1?, R¿2?, R'¿2?, R¿3?, R'¿3?, R¿4?, R'¿4?, R¿5?, R'¿5?, R¿6?, R'¿6?, R¿7?, R'¿7?, R¿8?, R'¿8?, R¿9?, R'¿9?, R¿10? and R'¿10?, X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, myocardial infarction, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.
(FR)La présente invention concerne des imitateurs, à faible poids moléculaire, de la superoxyde-dismutase, représentés par la formule (I) dans laquelle R, R', R¿1?, R'¿1?, R¿2?, R'¿2?, R¿3?, R'¿3?, R¿4?, R'¿4?, R¿5?, R'¿5?, R¿6?, R'¿6?, R¿7?, R'¿7?, R¿8?, R'¿8?, R¿9?, R'¿9?, R¿10? and R'¿10?, X, Y, Z et n sont tels que définis dans la présente invention. Ces imitateurs sont utiles comme agents thérapeutiques pour troubles et états pathologiques inflammatoires, lésion ischémique/de reperfusion, infarctus du myocarde, attaque, athérosclérose, et toutes autres pathologies dues à des altérations ou lésions tissulaires provoquées par des oxydants.
Designated States: AU, BB, BG, BR, BY, CA, CN, CZ, FI, HU, JP, KR, KZ, LK, LV, MG, MN, MW, NO, NZ, PL, RO, RU, SD, SK, UA, UZ.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)