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1. (WO1994015916) SELECTIVE LIGANDS OF RECEPTORS 5-HT1D-5HT1B DERIVED FROM INDOLE-PIPERAZINE USEFUL AS MEDICAMENTS

Pub. No.:    WO/1994/015916    International Application No.:    PCT/FR1993/001317
Publication Date: Jul 21, 1994 International Filing Date: Dec 29, 1993
IPC: C07D 209/16
C07D 409/12
Applicants: PIERRE FABRE MEDICAMENT
HALAZY, Serge
PEREZ, Michel
BRILEY, Michael
Inventors: HALAZY, Serge
PEREZ, Michel
BRILEY, Michael
Title: SELECTIVE LIGANDS OF RECEPTORS 5-HT1D-5HT1B DERIVED FROM INDOLE-PIPERAZINE USEFUL AS MEDICAMENTS
Abstract:
The present invention relates to new indole compounds derived from piperazine, to methods for their preparation and to therapeutical utilizations. The compounds have formula (I), wherein R1 is a hydrogen atom, a branched or linear alkyl radical or a phenyl, benzyl, cycloalkyl, polycycloalkyl, dibenzocycloalkyl, dibenzooxepine, dibenzoazepine, dibenzothiepine, benzopyrrolocycloalkyl, benzothienocycloalkyl, naphthyl radical, optionally substituted by one or a plurality of substituents selected amongst halogen atoms and alkyl, aryl, acyl, alkoxy and alkylthio radicals. Z is C = O, SO2 or (CH2)n wherein n is comprised between 1 and 5. The other radicals R comprise particularly a hydrogen atom.