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Machine translation
1. (WO1994015619) OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACID pH
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/015619    International Application No.:    PCT/US1994/000157
Publication Date: 21.07.1994 International Filing Date: 05.01.1994
Chapter 2 Demand Filed:    20.07.1994    
IPC:
C07H 21/00 (2006.01)
Applicants: THE JOHNS HOPKINS UNIVERSITY [US/US]; 300 Whitehead Hall, 3400 Charles Street, Baltimore, MD 21218 (US).
GENTA INCORPORATED [US/US]; 3550 General Atomics Court, San Diego, CA 92121 (US)
Inventors: MILLER, Paul, Scott; (US).
TS'O, Paul, On-Pong; (US).
SIMON, Lionel, Norton; (US)
Agent: BIGGS, Suzanne, L.; Lyon & Lyon, 34th floor, 611 West 6th Street, Los Angeles, CA 90017 (US)
Priority Data:
08/001,109 06.01.1993 US
Title (EN) OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACID pH
(FR) OLIGONUCLEOTIDES MODIFIES POUR AMELIORER LA STABILITE A pH ACIDE
Abstract: front page image
(EN)Acid resistant oligonucleotides modified by alkylation at the 2'-O-position are suitable for oral administration. Orally acceptable formulations prepared with the disclosed modified oligonucleotides as active ingredients are also provided.
(FR)Des oligonucléotides acido-résistants modifiés par alkylation au niveau de la position 2'-O peuvent être administrés par voie orale. Sont également décrites des formulations acceptables pour usage oral, préparées avec, comme principes actifs, les oligonucléotides modifiés.
Designated States: AU, CA, CN, JP, KR, NZ.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)