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1. (WO1994014845) MODIFIED TCF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/014845    International Application No.:    PCT/JP1993/001905
Publication Date: 07.07.1994 International Filing Date: 27.12.1993
IPC:
A61K 38/00 (2006.01), C07K 14/475 (2006.01)
Applicants: SNOW BRAND MILK PRODUCTS CO., LTD. [JP/JP]; 1-1, Naebocho 6-chome, Higashi-shi, Sapporo-shi, Hokkaido 065 (JP) (For All Designated States Except US).
YAMAGUCHI, Kyoji [JP/JP]; (JP) (For US Only).
SHIMA, Nobuyuki [JP/JP]; (JP) (For US Only).
MURAKAMI, Akihiko [JP/JP]; (JP) (For US Only).
GOTO, Masaaki [JP/JP]; (JP) (For US Only).
TSUDA, Eisuke [JP/JP]; (JP) (For US Only).
MASUNAGA, Hiroaki [JP/JP]; (JP) (For US Only).
TAKAHIRA, Reiko [JP/JP]; (JP) (For US Only).
OOGAKI, Fumiko [JP/JP]; (JP) (For US Only).
UEDA, Masatsugu [JP/JP]; (JP) (For US Only).
HIGASHIO, Kanji [JP/JP]; (JP) (For US Only)
Inventors: YAMAGUCHI, Kyoji; (JP).
SHIMA, Nobuyuki; (JP).
MURAKAMI, Akihiko; (JP).
GOTO, Masaaki; (JP).
TSUDA, Eisuke; (JP).
MASUNAGA, Hiroaki; (JP).
TAKAHIRA, Reiko; (JP).
OOGAKI, Fumiko; (JP).
UEDA, Masatsugu; (JP).
HIGASHIO, Kanji; (JP)
Agent: FUJINO, Seiya; Cross Side Kojimachi Bldg., 7F., 4, Kojimachi 5-chome, Chiyoda-ku, Tokyo 102 (JP)
Priority Data:
4/359747 28.12.1992 JP
Title (EN) MODIFIED TCF
(FR) FACTEUR CYTOTOXIQUE TUMORAL MODIFIE
Abstract: front page image
(EN)Modified TCF in which amino-acid residue(s) of the wild-type TCF responsible for glycosylation is (are) substituted or deleted so that at least one N-linked oligosaccharide chain is removed. The modified TCF have longer biological half-lives without loss of its biological activities. The modified TCFs are therapeutically important as agents for liver diseases or as anti-cancer drugs.
(FR)Facteur cytotoxique tumoral modifié, dans lequel le ou les résidu(s) amino-acide(s) du facteur cytotoxique tumoral de types naturels responsables de la glycosylation est ou sont substitués ou supprimés de manière à supprimer au moins une chaîne oligosaccharide de liaison N. Ce facteur cytotoxique tumoral ainsi modifié présente une demi-vie biologique plus longue sans perte des autres activités biologiques. Il présente une importance thérapeutique comme principe actif de médicaments contre les maladies du foie ou le cancer.
Designated States: AU, CA, FI, HU, JP, KR, NO, NZ, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)