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Machine translation
1. (WO1994014780) PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/014780    International Application No.:    PCT/GB1993/002556
Publication Date: 07.07.1994 International Filing Date: 15.12.1993
Chapter 2 Demand Filed:    08.06.1994    
IPC:
A61K 31/415 (2006.01), A61K 31/44 (2006.01), A61K 31/47 (2006.01), A61K 31/495 (2006.01), A61K 31/505 (2006.01), A61K 31/53 (2006.01), C07D 213/73 (2006.01), C07D 213/75 (2006.01), C07D 231/56 (2006.01), C07D 239/42 (2006.01), C07D 239/48 (2006.01), C07D 405/04 (2006.01), C07D 409/04 (2006.01), C07D 475/04 (2006.01)
Applicants: THE WELLCOME FOUNDATION LIMITED [GB/GB]; Unicorn House, 160 Euston Road, London NW1 2BP (GB) (For All Designated States Except US).
BIGHAM, Eric, Cleveland [US/US]; (US) (For US Only).
REINHARD, John, Frederick, Jr. [US/US]; (US) (For US Only).
MOORE, Philip, Keith [GB/GB]; (GB) (For US Only).
BABBEDGE, Rachel, Cecilia [GB/GB]; (GB) (For US Only).
KNOWLES, Richard, Graham [GB/GB]; (GB) (For US Only).
NOBBS, Malcolm, Stuart [GB/GB]; (GB) (For US Only).
BULL, Donald [GB/GB]; (GB) (For US Only)
Inventors: BIGHAM, Eric, Cleveland; (US).
REINHARD, John, Frederick, Jr.; (US).
MOORE, Philip, Keith; (GB).
BABBEDGE, Rachel, Cecilia; (GB).
KNOWLES, Richard, Graham; (GB).
NOBBS, Malcolm, Stuart; (GB).
BULL, Donald; (GB)
Agent: ROLLINS, Anthony, John; The Wellcome Foundation Limited, Langley Court, Beckenham, Kent BR3 3BS (GB)
Priority Data:
9226377.1 18.12.1992 GB
9303221.7 18.02.1993 GB
Title (EN) PYRIMIDINE, PYRIDINE, PTERIDINONE AND INDAZOLE DERIVATIVES AS ENZYME INHIBITORS
(FR) DERIVES DE PYRIMIDINE, DE PYRIDINE, DE PTERIDINONE ET D'INDAZOLE UTILISES COMME INHIBITEURS ENZYMATIQUES
Abstract: front page image
(EN)The use of a compound which binds at the tetrahydrobiopterin site of NO synthase for the treatment of conditions where there is an advantage in inhibiting neuronal NO synthase with little or no inhibition of endothelial NO synthase is disclosed. Pharmaceutical formulations comprising such compounds, and processes, including a novel process, for their preparation are also disclosed.
(FR)L'invention concerne l'utilisation d'un composé qui se lie au site de tétrahydrobioptérine de la NO synthétase pour le traitement d'états dans lesquels il est bénéfique d'inhiber la NO synthétase neuronale avec peu ou pas d'inhibition de la NO synthétase endothéliale. L'invention concerne également des formulations pharmaceutiques contenant de tels composés et des procédés, y compris un nouveau procédé, pour leur préparation.
Designated States: AU, CA, CZ, JP, KR, KZ, NO, NZ, PL, RU, UA, US, UZ.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)