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Pub. No.:    WO/1994/014776    International Application No.:    PCT/US1993/012436
Publication Date: 07.07.1994 International Filing Date: 21.12.1993
Chapter 2 Demand Filed:    16.06.1994    
C07D 211/18 (2006.01), C07D 211/70 (2006.01), C07D 213/24 (2006.01), C07D 223/16 (2006.01), C07D 243/04 (2006.01), C07D 243/14 (2006.01), C07D 243/24 (2006.01), C07D 267/14 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01), C07D 453/02 (2006.01)
Applicants: SMITHKLINE BEECHAM CORPORATION [US/US]; 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406-0939 (US) (For All Designated States Except US).
BONDINELL, William, Edward [US/US]; (US) (For US Only).
CALLAHAN, James, Francis [US/US]; (US) (For US Only).
HUFFMAN, William, Francis [US/US]; (US) (For US Only).
KEENAN, Richard, McCulloch [US/US]; (US) (For US Only).
KU, Thomas, Wen-Fu [US/US]; (US) (For US Only).
NEWLANDER, Kenneth, Allen [US/US]; (US) (For US Only).
SAMANEN, James, Martin [US/US]; (US) (For US Only).
UZINSKAS, Irene, Nijole [US/US]; (US) (For US Only)
Inventors: BONDINELL, William, Edward; (US).
CALLAHAN, James, Francis; (US).
HUFFMAN, William, Francis; (US).
KEENAN, Richard, McCulloch; (US).
KU, Thomas, Wen-Fu; (US).
NEWLANDER, Kenneth, Allen; (US).
SAMANEN, James, Martin; (US).
UZINSKAS, Irene, Nijole; (US)
Agent: KINZIG, Charles, M.; SmithKline Beecham Corporation, Corporate Patents - U.S. (UW2220), 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406 (US)
Priority Data:
07/992,885 21.12.1992 US
08/037,948 26.03.1993 US
Abstract: front page image
(EN)This invention relates to compounds of formulae (I), (II), (II), wherein A?1¿ is O, S, N-R?1¿ or CHR?1¿; A?4¿ is N-R?4¿ or CHR?4¿; R?2¿ is a sidechain containing an acid or ester group; R?1¿, R?4¿ and R?5¿ are substituents such as H, alkyl and aryl alkyl, and R?6¿ is a sidechain containing a nitrogen group; and pharmaceutically acceptable salts thereof, which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
(FR)L'invention concerne des composés des formules (I), (II), (III), dans lesquelles A?1¿ représente, O, S, N-R?1¿ ou CHR?1¿; A?4¿ représente N-R?4¿ ou CHR?4¿, R?2¿ représente une chaîne latérale contenant un groupe acide ou ester, R?1¿, R?4¿ et R?5¿ représentent des substituants tels que H, alkyle et aryle alkyle, et R?6¿ représente une chaîne latérale contenant un groupe azote et leurs sels pharmaceutiquement acceptables, lesquels composés sont efficaces pour inhiber l'aggrégation plaquettaire. L'invention concerne également des compositions pharmaceutiques mettant en ÷uvre ladite activité, ainsi qu'un procédé d'inhibition de l'aggrégation plaquettaire.
Designated States: AU, BB, BG, BR, BY, CA, CZ, FI, HU, JP, KP, KR, KZ, LK, LV, MG, MN, MW, NO, NZ, PL, RO, RU, SD, SK, UA, US, UZ, VN.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)