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Machine translation
1. (WO1994014749) DOUBLE ESTERS OF BENZOYLACRYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/014749    International Application No.:    PCT/HU1993/000068
Publication Date: 07.07.1994 International Filing Date: 10.12.1993
Chapter 2 Demand Filed:    21.06.1994    
IPC:
C07C 69/738 (2006.01)
Applicants: RICHTER GEDEON VEGYÉSZETI GYÁR RT. [HU/HU]; Gyömröi u. 19-21, H-1103 Budapest X. (HU) (For All Designated States Except US).
BALLÓ, Ildikó [HU/HU]; (HU) (For US Only).
FISCHER, János [HU/HU]; (HU) (For US Only).
PETÉNYI, Éva [HU/HU]; (HU) (For US Only).
EZER, Elemér [HU/HU]; (HU) (For US Only).
MATUZ, Judit [HU/HU]; (HU) (For US Only).
SÁGHY, Katalin [HU/HU]; (HU) (For US Only).
SZPORNY, László [HU/HU]; (HU) (For US Only).
HAJÓS, György [HU/HU]; (HU) (For US Only)
Inventors: BALLÓ, Ildikó; (HU).
FISCHER, János; (HU).
PETÉNYI, Éva; (HU).
EZER, Elemér; (HU).
MATUZ, Judit; (HU).
SÁGHY, Katalin; (HU).
SZPORNY, László; (HU).
HAJÓS, György; (HU)
Agent: DANUBIA; Bajcsy Zsilinszky ut 16, H-1368 Budapest (HU)
Priority Data:
P 92 04115 23.12.1992 HU
Title (EN) DOUBLE ESTERS OF BENZOYLACRYLIC ACIDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME
(FR) ESTERS DOUBLES D'ACIDES BENZOYLACRYLIQUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET LEUR PROCEDE DE PREPARATION
Abstract: front page image
(EN)The invention relates to novel double esters of benzoylacrylic acid of general formula (I), pharmaceutical compositions containing them and a process for their preparation. In general formula (I), R stands for a C¿1-4? alkyl group; or a phenyl group optionally substituted by one or more C¿1-4? alkoxy group(s); or 3-phenyl-3-oxo-1(E)-propenyl group; and n is 2, 3 or 4. The compounds of general formula (I) possess excellent antiulcer properties and a significant effect against $i(Helicobacter pylori) bacteria. Thus, they are useful for the therapeutic and/or prophylactic treatment of various ulcers of the oesophagus, stomach and duodenum.
(FR)Nouveaux esters doubles d'acide benzoylacrylique répondant à la formule générale (I), compositions pharmaceutiques les contenant et leur procédé de préparation. Dans la formule générale (I), R représente un groupe alkyle C¿1-4?; ou un groupe phényle éventuellement substitué par un ou plusieurs groupes alcoxy C¿1-4?; ou un groupe 3-phényl-3-oxo-1(E)-propényle; et n vaut 2,3 ou 4. Les composés de la formule générale (I) présentent d'excellentes propriétés antiulcéreuses et une activité significative dirigée contre les bactéries $i(Helicobacter pylori). De ce fait, ils sont utilisables dans le traitement et/ou la prévention de divers ulcères de l'÷sophage, de l'estomac et du duodénum.
Designated States: AU, CA, CZ, FI, JP, KR, KZ, LK, NO, NZ, PL, RO, RU, SK, UA, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)