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Machine translation
1. (WO1994014470) STABLE LIPOSOMAL FORMULATIONS OF LIPOPHILIC PLATINUM COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/014470    International Application No.:    PCT/US1993/012322
Publication Date: 07.07.1994 International Filing Date: 17.12.1993
Chapter 2 Demand Filed:    29.07.1994    
IPC:
A61K 9/127 (2006.01), A61K 31/28 (2006.01), C07F 15/00 (2006.01)
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West Seventh Street, Austin, TX 78701 (US)
Inventors: PEREZ-SOLER, Roman; (US).
HAN, Insook; (US).
KHOKHAR, Abdul, R.; (US)
Agent: GOODMAN, Kenneth, D.; Arnold, White & Durkee, P.O. Box 4433, Houston, TX 77210 (US)
Priority Data:
998,413 29.12.1992 US
Title (EN) STABLE LIPOSOMAL FORMULATIONS OF LIPOPHILIC PLATINUM COMPOUNDS
(FR) FORMULATIONS LIPOSOMALES STABLES DE COMPOSES DE PLATINE LIPOPHILES
Abstract: front page image
(EN)Lipophilic complexes having the structure DACH-Pt-R¿2? where DACH is diaminocyclohexane, and where R is a linear alkyl carboxylato group having from about 5 to about 18 carbon atoms, have desirable stability when entrapped within lipid bilayers, and exhibit high entrapment efficiency and in vivo antitumor activity.
(FR)Des complexes lipophiles ont la structure DACH-Pt-R¿2? dans laquelle DACH représente diaminocyclohexane, et où R représente un groupe carboxylato alkyle linéaire possédant d'environ 5 à environ 18 atomes de carbone. Ces complexes acquièrent la stabilité désirée lorsqu'ils sont emprisonnés dans des bicouches lipidiques, et ont une efficacité d'emprisonnement et une activité antitumorale in vivo importantes.
Designated States: AU, CA, JP.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)