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Machine translation
1. (WO1994014435) CYCLOALKYL AMINE BIS-ARYL SQUALENE SYNTHASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/014435    International Application No.:    PCT/US1993/012638
Publication Date: 07.07.1994 International Filing Date: 29.12.1993
Chapter 2 Demand Filed:    27.07.1994    
IPC:
C07C 217/52 (2006.01), C07D 215/14 (2006.01), C07D 263/57 (2006.01), C07D 277/66 (2006.01), C07D 307/80 (2006.01)
Applicants: RHONE-POULENC RORER PHARMACEUTICALS INC. [US/US]; 500 Arcola Road, P.O. Box 1200, Collegeville, PA 19426-0107 (US) (For All Designated States Except US).
ULLRICH, John, W. [US/US]; (US) (For US Only).
KIESOW, Terence, J. [US/US]; (US) (For US Only).
NEUENSCHWANDER, Kent, W. [US/US]; (US) (For US Only).
SCOTESE, Anthony, C. [US/US]; (US) (For US Only).
LEARN, Keith, S. [US/US]; (US) (For US Only).
DANKULICH, William, P. [US/US]; (US) (For US Only)
Inventors: ULLRICH, John, W.; (US).
KIESOW, Terence, J.; (US).
NEUENSCHWANDER, Kent, W.; (US).
SCOTESE, Anthony, C.; (US).
LEARN, Keith, S.; (US).
DANKULICH, William, P.; (US)
Agent: NICHOLSON, James, A.; Rhone-Poulenc Rorer, Inc., 500 Arcola Road, P.O. Box 1200, Collegeville, PA 19426-0107 (US)
Priority Data:
07/997,818 29.12.1992 US
Title (EN) CYCLOALKYL AMINE BIS-ARYL SQUALENE SYNTHASE INHIBITORS
(FR) INHIBITEURS DE SQUALENE SYNTHASE CYCLOALKYLAMINE BIS-ARYLE
Abstract: front page image
(EN)This invention relates to a class of novel polycyclic compounds containing a cycloalkyl ring having substituted thereon a primary amine and which is further linked or bridged to two mono- and/or bicyclic rings and which reduces levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
(FR)L'invention se rapporte à une classe de nouveaux composés polycycliques contenant un noyau cycloalkyle sur lequel est substituée une amine primaire et qui est également relié par une liaison ou un pont à deux noyaux monocycliques et/ou bicycliques et qui réduit les taux sériques de cholestérol dans le corps sans diminuer de manière notable la synthèse du métabolite mévalonique. L'invention se rapporte également à des compositions pharmacologiques et à un procédé de traitement destiné à faire baisser les niveaux sériques de cholestérol à l'aide des composés de cette invention.
Designated States: AT, AU, BB, BG, BR, CA, CH, CZ, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MG, MN, MW, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SK, UA, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)