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1. WO1994004167 - METAL-BASED FORMULATIONS WITH HIGH MICROBICIDAL EFFICIENCY VALUABLE FOR DISINFECTION AND STERILIZATION

Publication Number WO/1994/004167
Publication Date 03.03.1994
International Application No. PCT/US1992/007238
International Filing Date 26.08.1992
IPC
A01N 59/16 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
59Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
16Heavy metals; Compounds thereof
A01N 59/20 2006.01
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
59Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
16Heavy metals; Compounds thereof
20Copper
A61K 33/40 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
40Peroxides
CPC
A01N 59/16
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
59Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
16Heavy metals; Compounds thereof
A01N 59/20
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
59Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
16Heavy metals; Compounds thereof
20Copper
A61K 33/40
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
40Peroxides
Applicants
  • THE UNITED STATES OF AMERICA represented by THE SECRETARY, DEPARTEMENT OF HEALTH AND HUMAN SERVICES [US]/[US]
Inventors
  • SAGRIPANTI, Jose-Luis
Agents
  • GAGALA, Bruce, M.
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METAL-BASED FORMULATIONS WITH HIGH MICROBICIDAL EFFICIENCY VALUABLE FOR DISINFECTION AND STERILIZATION
(FR) FORMULATIONS A BASE METALLIQUE A HAUTE EFFICACITE ANTISEPTIQUE, CONVENANT A LA DESINFECTION ET A LA STERILISATION
Abstract
(EN)
Transition metals such as copper and iron, alone or in combination with each other or other transition metals, in aqueous solution are able to inactivate bacteria fungi, and viruses with an efficiency similar to that of substances usually recommended for disinfection and sterilization. Other transition metals can be used as disinfectant and sterilizing agents. The inactivating efficiency of such metals can be greatly enhanced by the addition of hydrogen peroxide, other peroxides, or pero-generating agents. The microbicidal potency of such mixtures can be increased even further in a ternary system composed of metal(s), peroxide, and a chelator, such as nitrilotriacetic acid (NTA). Different formulations of mixtures of metals and peroxide with or without NTA are provided. These are capable of inactivating viruses, bacteria, and fungi with an efficiency higher than that exhibited by substances currently in use. Also provided are methods for inactivating microorganisms for vaccine development, sterilizing or disinfecting medical devices and fluids, treating infectious disease, and assaying disinfectant, sterilizing, and antimicrobial substances and complex mixtures for microbicidal efficiency.
(FR)
Des métaux de transition tels que le cuivre et le fer, seuls ou combinés l'un avec l'autre ou avec d'autres métaux de transition en solution aqueuse, sont capables d'inactiver des champignons, des bactéries et des virus avec une efficacité analogue à celles des substances généralement recommandées pour la désinfection et la stérilisation. D'autres métaux de transition peuvent être utilisés comme agents de stérilisation et comme désinfectants. L'efficacité de tels métaux à inactiver les microbes peut être considérablement améliorée grâce à l'addition de peroxyde d'hydrogène, d'autres peroxydes ou d'agents pero-générateurs. La puissance antiseptique de tels mélanges peut être davantage accrue dans un système ternaire composé de métaux, de peroxyde, et d'un chélateur tel que l'acide nitrilotriacétique (NTA). Différentes formulations de mélanges de métaux et de peroxyde, avec ou sans NTA sont décrites. Ces formulations peuvent inactiver des virus, des bactéries et des champignons avec une efficacité supérieure à celle présentée par les substances actuellement utilisées. L'invention se rapporte également à des procédés permettant d'inactiver des microorganismes à des fins d'élaboration de vaccins, de stériliser ou de désinfecter des fluides et des dispositifs médicaux, de traiter des maladies infectieuses, et de doser des désinfectants, des substances de stérilisation et antimicrobiennes et des mélanges complexes afin d'en déterminer l'efficacité antiseptique.
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