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1. WO1994004127 - STABILIZED ENZYMATIC ANTIMICROBIAL COMPOSITIONS

Publication Number WO/1994/004127
Publication Date 03.03.1994
International Application No. PCT/US1993/007955
International Filing Date 24.08.1993
Chapter 2 Demand Filed 23.03.1994
IPC
A61K 8/66 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
66Enzymes
A61Q 11/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
11Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastes; Mouth rinses
CPC
A61K 8/66
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
64Proteins; Peptides; Derivatives or degradation products thereof
66Enzymes
A61Q 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
11Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Applicants
  • MONTGOMERY, Robert, E. [US]/[US]
Inventors
  • MONTGOMERY, Robert, E.
Agents
  • GROSS, Stephen, D.
Priority Data
07/934,77224.08.1992US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) STABILIZED ENZYMATIC ANTIMICROBIAL COMPOSITIONS
(FR) COMPOSITIONS ENZYMATIQUES ANTIMICROBIENNES STABILISEES
Abstract
(EN)
A stabilized aqueous composition capable of producing or, in the presence of saliva or other humoral fluid, leading to the production of antimicrobially effective concentrations of hypothiocyanite ions (OSCN-) are herein described. The composition contains an oxidoreductase enzyme and its specific substrate, for the purpose of producing hydrogen peroxide of at least the minimum effective concentration, and in addition, catalase for the destruction of hydrogen peroxide to prevent premature oxidoreductase enzyme decomposition. Optionally, a peroxidase enzyme may be included to act upon the aforementioned hydrogen peroxide, thereby oxidizing thiocyanate ions to produce the antimicrobial concentrations of hypothiocyanite ions (OSCN-).
(FR)
Compositions aqueuses stabilisées capables de produire ou, en présence de salive ou d'un autre liquide humoral, de conduire à la production de concentrations antimicrobiennes efficaces d'ions hypothiocyanite (OSCN-). La composition contient une oxydoréductase et son substrat spécifique, afin de produire du peroxyde d'hydrogène d'au moins la concentration efficace minimum, et en plus, de la catalase destinée à la destruction du peroxyde d'hydrogène afin d'empêcher une décomposition par oxydoréductase prématurée. On peut facultativement inclure une peroxydase afin d'agir sur le peroxyde d'hydrogène précité, oxydant ainsi les ions thiocyanate afin de produire les concentrations antimicrobiennes d'ions hypothiocyanite.
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