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1. WO1994003207 - HERPESVIRUS VACCINES

Publication Number WO/1994/003207
Publication Date 17.02.1994
International Application No. PCT/US1993/007245
International Filing Date 02.08.1993
Chapter 2 Demand Filed 25.01.1994
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/03 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
01DNA viruses
03Herpetoviridae, e.g. pseudorabies virus
CPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 31/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
22for herpes viruses
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C07K 2319/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
40containing a tag for immunodetection, or an epitope for immunisation
C07K 2319/61
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
61containing an enzyme fusion for detection (lacZ, luciferase)
Applicants
  • PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]/[US]
Inventors
  • KNIPE, David
Agents
  • BROOK, David, E.
Priority Data
07/922,91231.07.1992US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HERPESVIRUS VACCINES
(FR) VACCIN CONTRE L'HERPESVIRUS
Abstract
(EN)
A herpesvirus vaccine comprising a mutated herpesvirus suspended in a pharmaceutically acceptable carrier. The mutated herpesvirus is capable of infecting cells of the mammal to be vaccinated, but incapable of completing a replicative cycle, and it is capable of eliciting a protective immune response in that mammal. The mutation occurs in at least one gene encoding a protein essential for replication of the virus, so that the mutation renders the virus replication defective.
(FR)
Vaccin contre l'herpèsvirus, comprenant un herpèsvirus à mutatin en suspension dans un excipient pharmaceutiquement acceptable. L'herpèsvirus à mutation peut infecter les cellules du mammifère devant être vacciné, mais ne peut compléter un cycle de réplication, et il peut provoquer une réponse immunitaire protectrice chez ce mammifère. La mutation a lieu dans au moins un gène codant une protéine essentielle à la réplication du virus, de sorte que la mutation produit une déficience de réplication chez le virus.
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