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1. WO1994003161 - CONTROLLED RELEASE MORPHINE PREPARATION

Publication Number WO/1994/003161
Publication Date 17.02.1994
International Application No. PCT/SE1993/000642
International Filing Date 28.07.1993
Chapter 2 Demand Filed 07.12.1993
IPC
A61K 9/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A61K 9/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
28Dragees; Coated pills or tablets
A61K 31/485 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
485Morphinan derivatives, e.g. morphine, codeine
CPC
A61K 31/485
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
485Morphinan derivatives, e.g. morphine, codeine
A61K 9/2013
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
A61K 9/2826
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2806Coating materials
282Organic compounds, e.g. fats
2826Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
A61K 9/284
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2806Coating materials
2833Organic macromolecular compounds
284obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
A61P 25/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
Applicants
  • GACELL LABORATORIES AB [SE]/[SE] (AllExceptUS)
  • PERSSON, Christiane [SE]/[SE] (UsOnly)
  • WAXEGÅRD, Staffan [SE]/[SE] (UsOnly)
  • KULSTAD, Sören [SE]/[SE] (UsOnly)
  • FRIGREN, Lennart [SE]/[SE] (UsOnly)
Inventors
  • PERSSON, Christiane
  • WAXEGÅRD, Staffan
  • KULSTAD, Sören
  • FRIGREN, Lennart
Agents
  • AWAPATENT AB
Priority Data
9202250-829.07.1992SE
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CONTROLLED RELEASE MORPHINE PREPARATION
(FR) PREPARATION DE MORPHINE A LIBERATION REGULEE
Abstract
(EN)
The present invention concerns an oral morphine preparation having essentially complete bioavailability and, for the major part of the dissolution, an essentially zero order and essentially pH independent release of morphine for a period of at least 8 hours, preferably at least 12 hours, during which period less than 100 % is dissolved. In the preparation, the morphine, in the form of an easily soluble salt, is present in combination with a buffering agent in a preparation coated with a diffusion membrane.
(FR)
L'invention concerne une préparation de morphine buvable présentant une biodisponibilité pratiquement complète et, pour la plus grande partie de la dissolution, un degré de libération de morphine d'ordre zéro et essentiellement indépendant du pH pour une période d'au moins 8 heures, de préférence au moins 12 heures, pendant laquelle moins de 100 % est dissous. La préparation de morphine selon l'invention, qui se présente sous forme de sel facilement soluble dans l'eau, contient une combinaison d'agent tampon dans une préparation enrobée d'une membrane de diffusion.
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