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1. WO1994002167 - p53 VACCINE

Publication Number WO/1994/002167
Publication Date 03.02.1994
International Application No. PCT/US1993/007069
International Filing Date 22.07.1993
Chapter 2 Demand Filed 22.02.1994
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 2039/55594
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55588Adjuvants of undefined constitution
55594from bacteria
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/001151
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0011Cancer antigens
001148Regulators of development
00115Apoptosis related proteins, e.g. survivin, livin
001151p53
A61K 39/39
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
39characterised by the immunostimulating additives, e.g. chemical adjuvants
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/4746
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4746p53
Applicants
  • THE TRUSTEES OF PRINCETON UNIVERSITY [US]/[US]
Inventors
  • LEVINE, Arnold, J.
Agents
  • FEIT, Irving, N.
Priority Data
07/918,29222.07.1992US
08/015,49309.02.1993US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) p53 VACCINE
(FR) VACCIN p53
Abstract
(EN)
The subject invention provides a vaccine composition comprising a mutant or wild-type p53 protein in a form that, when presented to the immune system of a mammal, induces an effective immune response, i.e., either on the surface of an antigen presenting cell or combined with a pharmaceutically acceptable adjuvant. Further, the subject invention provides a method of inhibiting the growth of tumors in mammals comprising treating a mammal with an immunologically effective amount of a vaccine comprising the mutant or wild-type p53 protein.
(FR)
L'invention concerne une composition de vaccin comprenant une protéine p53 mutante ou de type sauvage sous une forme qui, lorsqu'elle est présentée au système immunitaire d'un mammifère, induit une réponse immunitaire efficace, c'est-à-dire soit à la surface d'une cellule présentant un antigène soit en combinaison avec un adjuvant pharmaceutiquement acceptable. L'invention se rapporte également à un procédé d'inhibition de la croissance des tumeurs chez le mammifère qui consiste à traiter un mammifère au moyen d'un vaccin immunologiquement acceptable contenant la protéine p53 mutante ou sauvage.
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