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Machine translation
1. (WO1994001773) PHOTOACTIVATION OF PROTEINS FOR CONJUGATION PURPOSES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/001773    International Application No.:    PCT/US1993/006388
Publication Date: 20.01.1994 International Filing Date: 06.07.1993
Chapter 2 Demand Filed:    03.02.1994    
IPC:
A61K 51/08 (2006.01), A61K 51/10 (2006.01), C07K 1/107 (2006.01), G01N 33/531 (2006.01), G01N 33/534 (2006.01)
Applicants: BIOMIRA INC. [CA/CA]; Edmonton Research Park, 2011-94 Street, Edmonton, Alberta T6N 1H1 (CA) (For All Designated States Except US).
SYKES, Thomas, R. [CA/CA]; (CA) (For US Only).
WOO, Thomas, K. [CA/CA]; (CA) (For US Only).
QI, Pei [CN/CA]; (CA) (For US Only).
NOUJAIM, Antony, A. [CA/CA]; (CA) (For US Only).
MCINNIS, Patricia, A. [US/US]; (US) (VN only)
Inventors: SYKES, Thomas, R.; (CA).
WOO, Thomas, K.; (CA).
QI, Pei; (CA).
NOUJAIM, Antony, A.; (CA)
Agent: COOPER, Iver, P.; Browdy and Neimark, 419 7th Street, N.W., Suite 300, Washington, DC 20004 (US)
Priority Data:
908,261 06.07.1992 US
Title (EN) PHOTOACTIVATION OF PROTEINS FOR CONJUGATION PURPOSES
(FR) PHOTOACTIVATION DE PROTEINES A DES FINS DE CONJUGAISON
Abstract: front page image
(EN)A protein containing one or more disulfide bonds, e.g., an antibody, is subjected to ultraviolet radiation to reduce one or more such bonds to reactive sulfhydryl groups; the resulting photoactivated protein is reacted with other chemical entity which is reactive with sulfhydryl, such as certain radiometals, chelating agents, drugs and toxins, so as to obtain a conjugate useful in, e.g., $i(in vitro) diagnosis, $i(in vivo) imaging, and therapy.
(FR)Une protéine contenant une ou plusieurs liaisons bisulfurées, par exemple un anticorps, est soumise à un rayonnement ultraviolet pour réduire au moins une de ces liaisons en groupes sulfhydryle réactifs; la protéine photoactivée obtenue est mise en réaction avec une autre entité chimique réagissant avec le sulfhydryle, telle que certains radiométaux, agents de chélation, médicaments et toxines pour obtenir un conjugué pouvant être utilisé, notamment, pour le diagnostic $i(in vitro), l'imagerie $i(in vivo) et la thérapie.
Designated States: AT, AU, BB, BG, BR, BY, CA, CH, CZ, DE, DK, ES, FI, GB, HU, JP, KP, KR, KZ, LK, LU, MG, MN, MW, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SK, UA, US, VN.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)