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1. (WO1994001393) NOVEL CHELATING AGENT, COMPLEX COMPOUND COMPOSED OF SAID AGENT AND METALLIC ATOM, AND DIAGNOSTIC AGENT CONTAINING SAID COMPOUND
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/001393    International Application No.:    PCT/JP1993/000331
Publication Date: 20.01.1994 International Filing Date: 22.03.1993
IPC:
A61K 49/06 (2006.01), C07C 229/16 (2006.01), C07C 237/04 (2006.01)
Applicants: THE GREEN CROSS CORPORATION [JP/JP]; 3-3, Imabashi 1-chome, Chuo-ku, Osaka-shi, Osaka 541 (JP) (For All Designated States Except US).
MORI, Fumio [JP/JP]; (JP) (For US Only).
OKANO, Tadashi [JP/JP]; (JP) (For US Only).
MURAKAMI, Kazuki [JP/JP]; (JP) (For US Only).
SHINTOME, Masakazu [JP/JP]; (JP) (For US Only).
MUKAI, Hiromichi [JP/JP]; (JP) (For US Only).
MIYAGI, Ikuko [JP/JP]; (JP) (For US Only).
IMAGAWA, Takashi [JP/JP]; (JP) (For US Only).
KIM, Sang-Won [KR/JP]; (JP) (For US Only).
MARUKAWA, Taro [JP/JP]; (JP) (For US Only).
KOZUKA, Takahiro [JP/JP]; (JP) (For US Only)
Inventors: MORI, Fumio; (JP).
OKANO, Tadashi; (JP).
MURAKAMI, Kazuki; (JP).
SHINTOME, Masakazu; (JP).
MUKAI, Hiromichi; (JP).
MIYAGI, Ikuko; (JP).
IMAGAWA, Takashi; (JP).
KIM, Sang-Won; (JP).
MARUKAWA, Taro; (JP).
KOZUKA, Takahiro; (JP)
Agent: TAKASHIMA, Hajime; Yuki Building, 3-9, Hiranomachi 3-chome, Chuo-ku, Osaka-shi, Osaka 541 (JP)
Priority Data:
4/200392 03.07.1992 JP
Title (EN) NOVEL CHELATING AGENT, COMPLEX COMPOUND COMPOSED OF SAID AGENT AND METALLIC ATOM, AND DIAGNOSTIC AGENT CONTAINING SAID COMPOUND
(FR) NOUVEAU CHELATEUR, COMPLEXE COMPOSE DUDIT CHELATEUR ET D'UN ATOME METALLIQUE, ET AGENT DIAGNOSTIQUE RENFERMANT LEDIT COMPLEXE
Abstract: front page image
(EN)A compound represented by general formula (I), a complex compound composed of the above compound and a metallic atom, and a diagnostic agent containing the complex compound, wherein m represents an integer of 1 to 3, R¿1? and R¿2? may be the same or different from each other and each represents hydrogen or lower alkyl, and R¿3?, R¿4?, R¿5? and R¿6? may be the same or different from one another and each represents hydroxy or (II), wherein n represents 0 or 1, X represents -NH- or -O-, Y represents alkylene, A represents hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and B represents alkyl or alkenyl, provided that two or three of the groups R¿3?, R¿4?, R¿5? and R¿6? are hydroxy and that when two of them are hydroxy groups, then the cases where R¿3? and R¿5? are hydroxy and where R¿4? and R¿6? are hydroxy are excluded. The first-mentioned compound is useful as a chelating agent and the complex compound has excellent characteristics as a contrast medium for diagnostic imaging.
(FR)L'invention décrit un composé représenté par la formule générale (I), un complexe constitué du composé précité et d'un atome métallique, ainsi qu'un agent diagnotisque renfermant ledit complexe. Dans cette formule, m représente un entier compris entre 1 et 3, R¿1? et R¿2? peuvent être identiques ou différents et chacun représente hydrogène ou alkyle inférieur, et R¿3?, R¿4?, R¿5? et R¿6? peuvent être identiques ou différents et chacun représente hydroxy ou (II), où n vaut 0 ou 1, X représente -NH- ou bien -O-, Y représente akylène, A représente hydrogène, alkyle inférieur, alcoxy inférieur, halogène ou trifluorométhyle, et B représente alkyle ou alcényle, à condition que deux ou trois des groupes R¿3?, R¿4?, R¿5? et R¿6? soient hydroxy et que lorsque deux d'entre eux sont des groupes hydroxy, soient exclus les cas où R¿3? et R¿5? sont hydroxy et où R¿4? et R¿6? sont hydroxy. Le premier composé cité est utile comme chélateur, et le complèxe possède d'excellentes caractéristiques comme substance de contraste pour l'imagerie diagnostique.
Designated States: CA, KR, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)