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1. (WO1994001140) ECHOGRAPHIC CONTRAST AGENT COMPOSITION

Pub. No.:    WO/1994/001140    International Application No.:    PCT/EP1993/001705
Publication Date: Jan 20, 1994 International Filing Date: Jul 2, 1993
IPC: A61K 49/22
Applicants: BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH
LINDER, Rudolf
BELLER, Klaus-Dieter
Inventors: LINDER, Rudolf
BELLER, Klaus-Dieter
Title: ECHOGRAPHIC CONTRAST AGENT COMPOSITION
Abstract:
Micro-gas bubble compositions reconstitutable in aqueous systems and useful as echographic contrast agents are prepared by lyophilising aqueous emulsions which contain parenterally acceptable emulsifiers, apolar liquids and lipid-soluble or water-insoluble builders. These lyophilisates are characterised by a remarkable storage stability and when reconstituted with water they produce microbubble-containing echographic contrast agents characterised by microbubbles having a very small diameter and a surprisingly high stability.