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1. (WO1993024510) PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1993/024510 International Application No.: PCT/FR1993/000498
Publication Date: 09.12.1993 International Filing Date: 24.05.1993
Chapter 2 Demand Filed: 20.12.1993
IPC:
C07F 9/6561 (2006.01) ,C07H 19/10 (2006.01) ,C07H 19/20 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
547
Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6561
containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
10
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
20
with the saccharide radical being esterified by phosphoric or polyphosphoric acids
Applicants:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR/FR]; 15, quai Anatole-France F-75007 Paris, FR (AllExceptUS)
GOSSELIN, Gilles [FR/FR]; FR (UsOnly)
IMBACH, Jean-Louis [FR/FR]; FR (UsOnly)
Inventors:
GOSSELIN, Gilles; FR
IMBACH, Jean-Louis; FR
Agent:
WARCOIN, Jacques; Cabinet Regimbeau 26, avenue Kléber F-75116 Paris, FR
Priority Data:
92/0638325.05.1992FR
93/0411707.04.1993FR
Title (EN) PHOSPHOTRIESTER-TYPE BIOLOGICALLY ACTIVE COMPOUNDS
(FR) COMPOSES BIOLOGIQUEMENT ACTIFS DE TYPE PHOSPHOTRIESTERS
Abstract:
(EN) Phosphotriester compound of general formula (I); wherein R is a radical - (CH2)n - S - X in which X is a radical (a) or -S-U, Z being O or S, and Y and U denote an alkyl, aryl or osidic radical, optionally substituted in particular by an OH, SH or NH2 group, and n is from 1 to 4, preferably 1 or 2, and Nu is a radical consisting of a biologically active compound residue or the dephosphorylated residue of a compound that is biologically active when it carries a phosphate or phosphonate group.
(FR) La présente invention a pour objet un composé phosphotriester répondant à la formule générale (I) dans laquelle: R est un radical - (CH2)n - S - X où X représente un radical (a) ou -S-U, Z étant O ou S et, Y et U représentant un radical alkyle, aryle ou osidique, éventuellement substitué notamment par un groupe OH, SH ou NH2 et, n est égal à 1 à 4 de préférence 1 ou 2 et, Nu est un radical consistant en un reste d'un composé biologiquement actif ou le reste déphosphorylé d'un composé qui est biologiquement actif lorsqu'il porte un groupe phosphate ou phosphonate.
Designated States: CA, JP, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
EP0642528JPH07507068CA2136622