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Machine translation
1. (WO1993020200) MODIFIED CELLS AND METHOD OF TREATMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1993/020200    International Application No.:    PCT/GB1993/000686
Publication Date: 14.10.1993 International Filing Date: 02.04.1993
Chapter 2 Demand Filed:    26.10.1993    
IPC:
A61K 38/00 (2006.01), C07K 14/72 (2006.01), C07K 14/82 (2006.01), C12N 15/11 (2006.01)
Applicants: IMPERIAL CANCER RESEARCH TECHNOLOGY LIMITED [GB/GB]; Sardinia House, Sardinia Street, London WC2A 3NL (GB) (For All Designated States Except US).
EVAN, Gerard, Ian [GB/GB]; (GB) (For US Only)
Inventors: EVAN, Gerard, Ian; (GB)
Agent: BASSETT, Richard, S.; Eric Potter Clarkson, St Mary's Court, St Mary's Gate, Nottingham NG1 1LE (GB)
Priority Data:
9207275.0 02.04.1992 GB
9207276.8 02.04.1992 GB
Title (EN) MODIFIED CELLS AND METHOD OF TREATMENT
(FR) CELLULES MODIFIEES ET PROCEDE DE TRAITEMENT
Abstract: front page image
(EN)$i(Myc)-induced cell death is inhibited in cultured cells, for example hybridoma cells, by expressing bc12. $i(Myc)-induced cell death is de-inhibited in tumour cells by administering bc12 antisense oligonucleotides. Compounds which modulate apoptosis may be detected in an assay using a proto-oncogene such as $i(Myc).
(FR)Inhibition de la mort cellulaire provoquée par $i(Myc) dans les cellules cultivées, par exemple les cellules d'hybridome, par l'expression de bc12. On peut inhiber la mort cellulaire provoquée par $i(Myc) dans les cellules tumorales en administrant des oligonucléotides anti-sens de bc12. On peut détecter dans un dosage les composés modulateurs de l'apoptose en utilisant un proto-oncogène tel que $i(Myc).
Designated States: GB, JP, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)