WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |

Search International and National Patent Collections
World Intellectual Property Organization
Machine translation
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1993/020092    International Application No.:    PCT/GB1993/000694
Publication Date: 14.10.1993 International Filing Date: 02.04.1993
Chapter 2 Demand Filed:    08.10.1993    
C07F 9/655 (2006.01), C07H 21/00 (2006.01)
Applicants: ZENECA LIMITED [GB/GB]; 15 Stanhope Gate, London W1Y 6LN (GB) (For All Designated States Except US).
McLEAN, Michael, Joseph [GB/GB]; (GB) (For US Only).
HOLLAND, David [GB/GB]; (GB) (For US Only).
GARMAN, Andrew, John [GB/GB]; (GB) (For US Only).
SHEPPARD, Robert, Charles [GB/GB]; (GB) (For US Only)
Inventors: McLEAN, Michael, Joseph; (GB).
HOLLAND, David; (GB).
GARMAN, Andrew, John; (GB).
SHEPPARD, Robert, Charles; (GB)
Agent: MANNION, Sally, Kim; Group Patent Services Department, P.O. Box 6, Bessemer Road, Welwyn Garden City, Hertfordshire AL7 1HD (GB)
Priority Data:
9207381.6 03.04.1992 GB
Abstract: front page image
(EN)A method for the synthesis of a plurality of oligonucleotides comprising the steps of (i) forming a first oligonucleotide on a first cleavable link attached to a solid support; (ii) attaching to the first oligonucleotide a cleavable linker moiety; (iii) forming a second oligonucleotide on the cleavable linker moiety; and (iv) cleaving the first cleavable link and the cleavable linker moiety to give a plurality of oligonucleotides; wherein the cleavable linker moiety is of formula (1), in which A?1¿, A?2¿ and E are as defined herein, and novel compounds which may be used in the operation of the method.
(FR)Procédé de synthèse d'une pluralité d'oligonucléotides, consistant (i) à former un premier oligonucléotide sur une première liaison clivable reliée à un support solide; (ii) à fixer au premier oligonucléotide une fraction de linker clivable; (iii) à former un second oligonucléotide sur la fraction de linker clivable; et (iv) à cliver la première liaison clivable et la fraction de linker clivable afin d'obtenir une pluralité d'oligonucléotides. Ladite fraction de linker clivable répond à la formule (I), dans laquelle A?1¿, A?2¿ et E ont les notations définies dans la description. L'invention concerne également de nouveaux composés utilisables dans la mise en ÷uvre dudit procédé.
Designated States: AT, AU, BB, BG, BR, CA, CH, CZ, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MG, MN, MW, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SK, UA, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)