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1. (WO1993019746) TOPICAL ADMINISTRATION OF TOREMIFENE AND ITS METABOLITES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1993/019746    International Application No.:    PCT/FI1993/000119
Publication Date: 14.10.1993 International Filing Date: 25.03.1993
Chapter 2 Demand Filed:    29.10.1993    
IPC:
A61K 31/135 (2006.01), A61K 47/48 (2006.01)
Applicants: ORION-YHTYMÄ OY [FI/FI]; Orionintie 1, SF-02200 Espoo (FI) (For All Designated States Except US).
DEGREGORIO, Michael, William [US/US]; (US) (For US Only).
KURKELA, Kauko, Oiva, Antero [FI/FI]; (FI) (For US Only)
Inventors: DEGREGORIO, Michael, William; (US).
KURKELA, Kauko, Oiva, Antero; (FI)
Agent: ORION CORPORATION; Orion-Farmos Pharmaceuticals, Patent Department, P.O. Box 65, FIN-02101 Espoo (FI)
Priority Data:
9207437.6 03.04.1992 GB
Title (EN) TOPICAL ADMINISTRATION OF TOREMIFENE AND ITS METABOLITES
(FR) ADMINISTRATION TOPIQUE DE TOREMIFENE ET DE SES METABOLITES
Abstract: front page image
(EN)Topical preparations containing as active ingredient toremifene or one of its metabolites N-demethyltoremifene or 4-hydroxy-toremifene or their pharmaceutically acceptable non-toxic salts are useful for the treatment of cancers localized in the skin or on a short distance from the skin such as metastatic lesions of breast cancer. They may also be used in adjuvant therapy of breast cancer and in the reversal of multidrug resistance of cancer cells to cytotoxic drugs. Such topical preparations are of particular interest in the treatment of melanoma, lymphoma, Kaposi's sarcoma and fungoides mycosis.
(FR)Préparations topiques renfermant comme substances actives un torémifène ou un de ses métabolites N-déméthyltorémifène ou 4-hydroxy-torémifène, ou leurs sels non toxiques pharmaceutiquement acceptables. Ces préparations permettent de traiter les cancers localisés de la peau ou à faible distance de la peau, tels que les lésions métastatiques du cancer du sein. Ces préparations peuvent également être employées dans une thérapie adjuvante du cancer du sein et pour contrer la résistance des cellules cancéreuses aux substances cytotoxiques. Ces préparations topiques présentent un intérêt particulier dans le traitement du mélanome, du lymphome, du sarcome de Kaposi et des mycoses fongoïdes.
Designated States: AT, AU, BY, CA, CH, DE, DK, ES, FI, GB, HU, JP, LU, NL, NO, NZ, PT, RU, SE, UA, US, UZ.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)