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1. (WO1993019745) METHOD OF TREATING CLOSTRIDIUM DIFFICILE COLITIS AND CHOLERA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1993/019745    International Application No.:    PCT/US1993/003026
Publication Date: 14.10.1993 International Filing Date: 01.04.1993
Chapter 2 Demand Filed:    01.11.1993    
IPC:
A61K 31/00 (2006.01), A61K 31/12 (2006.01), A61K 31/335 (2006.01), A61K 31/365 (2006.01), A61K 31/405 (2006.01), A61K 31/44 (2006.01), A61K 31/4439 (2006.01), A61K 31/47 (2006.01), A61K 31/55 (2006.01), A61K 31/551 (2006.01)
Applicants: THE UNIVERSITY OF VIRGINIA PATENTS FOUNDATION [US/US]; Towers Office Building, Suite 1-110, 1224 West Main Street, Charlottesville, VA 22903 (US)
Inventors: GUERRANT, Richard, L.; (US).
GUODONG, Fang; (US).
FONTELES, Manasses, C.; (US)
Agent: PARKER, Sheldon, H.; Suite 300, 300 Preston Avenue, Charlottesville, VA 22902 (US)
Priority Data:
07/861,620 01.04.1992 US
08/040,444 01.04.1993 US
Title (EN) METHOD OF TREATING CLOSTRIDIUM DIFFICILE COLITIS AND CHOLERA
(FR) PROCEDE DE TRAITEMENT DU CHOLERA ET DE LA COLITE ASSOCIEE AU CLOSTRIDIUM DIFFICILE
Abstract: front page image
(EN)The invention relates to the treatment of antibiotic associated colitis, typically due to Clostridium difficile using Platelet Activating Factor antogonists, such as WEB 2170, SR 27417 or BN 52021, or the cyclooxygenase antagonists, such as indomethacin. The PAF antagonists BN 52021 and SR 27417 and the cyclooxygenase antagonist indomethacin were effective in inhibiting the secretory effects caused by C. difficile Toxin A and even by Cholera toxin.
(FR)L'invention se rapporte au traitement de la colite associée à un antibiotique, en particulier provoquée par Clostridium difficile, au moyen d'antagonistes du facteur d'activation plaquettaire (PAF) tels que WEB 2170, SR 27417, ou BN 52021, ou des antagonistes de cyclooxygénase tels que l'indométhacine. Les antagonistes de PAF, BN 52021 et SR 27417 et l'antagoniste de cyclooxygénase, indométhacine, ont inhibé efficacement les effets sécrétoires de la toxine A de C difficile et même de la toxine du choléra.
Designated States: AU, BR, CA, FI, HU, JP, KP, KR, LK, MG, MN, MW, NO, PL, RO, RU, SD.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)