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1. (WO1993017712) CONJUGATES FORMED FROM HEAT SHOCK PROTEINS AND OLIGO- OR POLYSACCHARIDES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1993/017712 International Application No.: PCT/EP1993/000516
Publication Date: 16.09.1993 International Filing Date: 08.03.1993
Chapter 2 Demand Filed: 01.10.1993
IPC:
A61K 38/00 (2006.01) ,A61K 39/00 (2006.01) ,A61K 39/095 (2006.01) ,A61K 47/48 (2006.01) ,C07K 14/205 (2006.01) ,C07K 14/35 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
095
Neisseria
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
205
from Campylobacter (G)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
35
from Mycobacteriaceae (F)
Applicants:
BIOCINE SPA [IT/IT]; Via Fiorentina, 1 I-53100 Siena, IT (AllExceptUS)
RAPPUOLI, Rino [IT/IT]; IT (UsOnly)
COSTANTINO, Paolo [IT/IT]; IT (UsOnly)
VITI, Stefano [IT/IT]; IT (UsOnly)
NORELLI, Francesco [IT/IT]; IT (UsOnly)
Inventors:
RAPPUOLI, Rino; IT
COSTANTINO, Paolo; IT
VITI, Stefano; IT
NORELLI, Francesco; IT
Agent:
HALLYBONE, Huw, George; Carpmaels & Ransford 43 Bloomsbury Square London WC1A 2RA, GB
Priority Data:
FI92A00005806.03.1992IT
Title (EN) CONJUGATES FORMED FROM HEAT SHOCK PROTEINS AND OLIGO- OR POLYSACCHARIDES
(FR) COMPOSES CONJUGUES OBTENUS A PARTIR DE PROTEINES DU CHOC THERMIQUE ET D'OLIGOSACCHARIDES OU DE POLYSACCHARIDES
Abstract:
(EN) A conjugate compound comprises at least one heat shock protein or portion thereof including at least one immunostimulatory domain and at least one capsular oligosaccharide or polysaccharide of a pathogenic bacteria. The compound comprises oligosaccharides of the Meningococci C (MenC) group and a heat shock protein selected from $i(M. bovis) BCG GroEl-type 65kDa hsp (hspR65), recombinant $i(M. tuberculosis) DnaK-type 70kDa hsp (hspR70) and a heat shock protein from $i(H. pylori). The conjugate compounds are useful in the preparation of vaccines to prevent bacterial infection.
(FR) Un composé conjugué comprend au moins une protéine du choc thermique ou une partie de celle-ci comprenant au moins un domaine immunostimulateur et au moins un oligosaccharide ou polysaccharide capsulaire d'une bactérie pathogène. Le composé comprend des oligosaccharides du groupe Meningococci C (Men C) et une protéine du choc thermique choisi entre hsp de $i(M. bovis) BCG type GroEl de 65kDa (hspR65), hsp recombiné de $i(M. tuberculosis) type DnaK de 70kDa (hspR70) et une protéine du choc thermique provenant de $i(H. pylori). Ces composés conjugués peuvent être utilisés dans la préparation de vaccins destinés à prévenir les infections bactériennes.
Designated States: AT, AU, BB, BG, BR, CA, CH, CZ, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MG, MN, MW, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SK, UA, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0632727US6403099JPH07504423CA2131551AU1993037462