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1. (WO1993007151) CYCLIC KETAL DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1993/007151 International Application No.: PCT/EP1992/002294
Publication Date: 15.04.1993 International Filing Date: 02.10.1992
Chapter 2 Demand Filed: 13.04.1993
IPC:
C07D 493/08 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
08
Bridged systems
Applicants:
GLAXO GROUP LIMITED [GB/GB]; Glaxo House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
RUDD, Brian, Arthur, Michael [GB/GB]; GB (UsOnly)
COX, Brian [GB/GB]; GB (UsOnly)
HALL, Richard, Malcom [GB/GB]; GB (UsOnly)
HALE, Richard, Stephen [GB/GB]; GB (UsOnly)
SIDEBOTTOM, Philip, James [GB/GB]; GB (UsOnly)
Inventors:
RUDD, Brian, Arthur, Michael; GB
COX, Brian; GB
HALL, Richard, Malcom; GB
HALE, Richard, Stephen; GB
SIDEBOTTOM, Philip, James; GB
Agent:
CAFFIN, Lee ; Glaxo Holdings p.l.c. Glaxo House Berkeley Avenue Greenford Middlesex UB6 0NN, GB
Priority Data:
9121380.108.10.1991GB
Title (EN) CYCLIC KETAL DERIVATIVES
(FR) DERIVES DE CETAL CYCLIQUE
Abstract:
(EN) Compounds are described of formula (I) and salts thereof; wherein R1 represents a hydrogen atom or an acetyl group; R2, R3 and R4 may each independently represent a hydrogen atom or a methyl group; and R5 represents a hydrogen atom or a group (II). These compounds inhibit the enzyme squalene synthase and/or are intermediates for the preparation of compounds which inhibit the enzyme squalene synthase. Compounds of the invention may be formulated for use in a variety of conditions where a lowering of the level of blood plasma cholesterol in animals would be beneficial and for use in combating fungal infections in animals.
(FR) On décrit des composés de la formule (1) et leurs sels; où R1 représente un atome d'hydrogène ou un groupe acétyle; R2, R3 et R4 peuvent chacun représenter indépendamment un atome d'hydrogène ou un groupe méthyle; et R5 représente un atome d'hydrogène ou un groupe (II). Ces composés inhibent la squalène synthèse, et/ou peuvent être utilisés comme intermédiaires dans la préparation de composés inhibant la squalène synthase. Les composés de cette invention peuvent être formulés de façon à pouvoir traiter différents états nécessitant une réduction du niveau de cholestérol de plasma sanguin chez des mammifères, et pour lutter contre les infections fongiques chez les mammifères.
Designated States: AT, AU, BB, BG, BR, CA, CH, CS, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MG, MN, MW, NL, NO, PL, RO, RU, SD, SE, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1992026866