Processing

Please wait...

Settings

Settings

Goto Application

1. WO1993004064 - CYCLIC URETHANES USEFUL AS ANTIARRHYTHMIC AND ANTIFIBRILLATORY AGENTS

Publication Number WO/1993/004064
Publication Date 04.03.1993
International Application No. PCT/US1992/006682
International Filing Date 10.08.1992
Chapter 2 Demand Filed 24.02.1993
IPC
C07D 413/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 413/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
CPC
A61P 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
06Antiarrhythmics
C07D 413/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
C07D 413/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 413/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14containing three or more hetero rings
Applicants
  • PROCTER & GAMBLE PHARMACEUTICALS, INC. [US]/[US]
Inventors
  • PELOSI, Stanford, Salvatore, Jr.
  • YU, Chia-Nien
Agents
  • REED, T., David
Priority Data
744,86514.08.1991US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CYCLIC URETHANES USEFUL AS ANTIARRHYTHMIC AND ANTIFIBRILLATORY AGENTS
(FR) NOUVELLES UREES CYCLIQUES UTILISEES COMME AGENTS ANTIARYTHMIQUES ET ANTIFIBRILLANTS
Abstract
(EN)
The novel cyclic urethanes, and their pharmaceutically-acceptable salts and esters, described herein which are useful as antiarrhythmic and antifibrillatory agents and have general structure (I), wherein (a) X is a saturated or unsaturated, 5-, 6-, or 7-membered heterocycle or carbocycle; (b) R is selected from the group consisting of covalent bond, nil, heteroatom, carbonyl, heterocyclic ring, carbocyclic ring, alkyl, alkenyl, alkoxy, alkylamino, arylalkyl, aryloxy, acyl, acyloxy, and acylamino; (c) Y is a substituted or unsubstituted, saturated or unsaturated, 5-, 6-, or 7-membered heterocyclic ring or carbocyclic ring, or is nil; and wherein when R is nil, X and Y are fused ring systems; and when R is a covalent bond, X and Y are ring systems linked through a covalent bond; and when Y is nil, R is a covalent bond, and X is a carbocycle bound to L through R; (d) R1, R2, and R3 are independently selected from the group consisting of nil, Cl, F, Br, NH2, CF3, OH, SO3H, CH3SO2NH, COOH, alkoxy, alkyl, alkoxycarbonyl, hydroxyalkyl, carboxyalkyl, aminoalkyl, acylamino, and acyloxy; (e) L is selected from the group consisting of alkylamino, alkenylamino, alkylimino, alkenylimino and acylamino; wherein the nitrogen atom thereof is bound to the nitrogen atom at the 3-position of the cyclic urethane ring moiety; (f) R4 is selected from the group consisting of alkyl, alkenyl, alkynyl, alkylacyl, and heteroalkyl; (g) A is a substituted or unsubstituted, saturated or unsaturated, straight-chain or branched, C1-C8 heteroalkyl; or a substituted or unsubstituted, saturated or unsaturated heterocycle having 6- or 7-members which may not have an oxygen atom; and A has one nitrogen atom which is adjacent to R4; and (h) R5 is a substituted or unsubstituted C1 or C2 alkyl; and the pharmaceutically-acceptable salts and esters thereof.
(FR)
Les nouvelles urées cycliques de la présente invention sont utilisées comme agents antiarythmiques et antifibrillants, et ont la structure générale (I) dans laquelle (a) X est un hétérocycle ou carbocycle saturé ou insaturé, à 5, 6 ou 7 éléments; (b) R est sélectionné dans le groupe composé par une liaison covalente, zéro, héteratome, carbonyle, cycle hétérocyclique, cycle carbocyclique, alkyle, alcényle, alcoxy, alkylamino, arylalkyle, aryloxy, acyle, acyloxy et acylamino; (c) Y est un cycle hétérocyclique ou carbocyclique à 5, 6 ou 7 éléments, substitué ou non substitué, saturé ou insaturé, ou est nul; et dans laquelle si R est nul, X et Y sont des systèmes de cycles fusionnés; et si R est une liaison covalente, X et Y sont des systèmes de cycles liés par une liaison covalente; et si Y est nul, R est une liaison covalente et X est lié à L par R; (d) R1, R2 et R3 sont sélectionnés indépendamment dans le groupe composé par zéro, Cl, F, Br, NH2, CF3, OH, SO3H, CH3SO2NH, COOH, alcoxy, alkyle, alcoxycarbonyle, hydroxyalkyle, carboxyalkyle, aminoalkyle, acylamino, et acyloxy; (e) L est sélectionné dans le groupe composé par alkylamino, alcénylamino, alkylimino, alcénylimino, et acylamino, dans lequel l'atome d'azote de celui-ci est lié à l'atome d'azote, en position 3, de la fraction cyclique de l'urée; (f) R4 est sélectionné dans le groupe composé par alkyle, alcényle, alkynyle, alkylacyle et hétéroalkyle; (g) A est un hétéroalkyle C1-C8 substitué ou non substitué, saturé ou insaturé, à chaîne droite ou ramifiée, ou un hétérocycle substitué ou non substitué saturé ou insaturé possédant 5, 6, ou 7 éléments; et comporte un atome d'azote adjacent à R4; et (h) R5 est un alkyle C1 ou C2 substitué ou non substitué, et par leurs sels et esters pharmaceutiquement acceptables.
Latest bibliographic data on file with the International Bureau