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1. WO1993003731 - DRUGS FOR TOPICAL APPLICATION OF SEX STEROIDS IN THE TREATMENT OF DRY EYE SYNDROME, AND METHODS OF PREPARATION AND APPLICATION

Publication Number WO/1993/003731
Publication Date 04.03.1993
International Application No. PCT/US1991/005863
International Filing Date 17.08.1991
Chapter 2 Demand Filed 27.07.1992
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 31/565 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
565not substituted in position 17 beta by a carbon atom, e.g. oestrane, oestradiol
CPC
A61K 31/565
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
565not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
A61K 9/0048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0048Eye, e.g. artificial tears
Y10S 514/912
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
514Drug, bio-affecting and body treating compositions
912Ophthalmic
Y10S 514/914
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
514Drug, bio-affecting and body treating compositions
912Ophthalmic
914Inflammation
Applicants
  • LUBKIN, Virginia [US]/[US]
Inventors
  • LUBKIN, Virginia
Agents
  • WINTER, Richard, C.
  • POPPER, Horward, R.
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DRUGS FOR TOPICAL APPLICATION OF SEX STEROIDS IN THE TREATMENT OF DRY EYE SYNDROME, AND METHODS OF PREPARATION AND APPLICATION
(FR) MEDICAMENTS POUR L'APPLICATION TOPIQUE DE STEROIDES SEXUELS DANS LE TRAITEMENT DE LA KERATOCONJONCTIVITE SECHE, PROCEDES DE PREPARATION ET D'APPLICATION DESDITS MEDICAMENTS
Abstract
(EN)
A topical drug application for the alleviation of keratoconjunctivitis sicca (dry eye syndrome) is comprised of a solution of sex steroids or their derivatives suspended or dissolved in a vehicle, and the method of preparation and application of the same. In the preferred embodiments, the sex steroid consists essentially of conjugated estrogen in a lipid vehicle or a derivative of estrogen known as 17 beta-Estradiol 3-phosphate disodium dissolved in an aqueous vehicle having a pH of between 6 and 8.
(FR)
Application topique d'un médicament destiné à soulager la kératoconjonctivite sèche, composé d'une solution de stéroïdes sexuels ou de leurs dérivés en suspension ou dissous dans un excipient, et procédé de préparation et d'application dudit médicament. Dans les modes de réalisation préférés, le stéroide sexuel est essentiellement composé d'÷strogène conjugué dans un excipient liquide ou d'un dérivé d'÷strogène connu sous le nom de 17 bêta-Estradiol 3-phosphate disodium dissous dans un excipient aqueux ayant un pH situé entre 6 et 8.
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