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1. WO1992018484 - 3-AMINO-5-ARYLPYRAZOLE-4-ACETIC ACID DERIVATIVES EXHIBITING THERAPEUTIC EFFECTS

Publication Number WO/1992/018484
Publication Date 29.10.1992
International Application No. PCT/US1992/002379
International Filing Date 25.03.1992
Chapter 2 Demand Filed 04.11.1992
IPC
C07D 231/38 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02not condensed with other rings
10having two or three double bonds between ring members or between ring members and non-ring members
14with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
CPC
C07D 231/38
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02not condensed with other rings
10having two or three double bonds between ring members or between ring members and non-ring members
14with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
Applicants
  • A.H. ROBINS COMPANY, INCORPORATED [US]/[US]
Inventors
  • TAYLOR, Chandler, Roy, Jr.
  • STAUFFER, Harold, Fisher, Jr.
  • TOMCZUK, Bruce, Edward
Agents
  • ALICE, Ronald, W.
  • PORTER, Graham, Ronald
Priority Data
684,32512.04.1991US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) 3-AMINO-5-ARYLPYRAZOLE-4-ACETIC ACID DERIVATIVES EXHIBITING THERAPEUTIC EFFECTS
(FR) DERIVES D'ACIDE 3-AMINO-5-ARYLPYRAZOLE-4-ACETIQUE PRESENTANT DES EFFETS THERAPEUTIQUES
Abstract
(EN) This invention provides novel pyrazole-4-acetic acid derivatives corresponding to formula (I) where Y is hydrogen or halogen, C1-C4 alkyl or C1-C4 alkoxy substituent; Z is a hydroxy, C1-C4 alkoxy or -NRR substituent; and R is hydrogen or a C1-C4 alkyl substituent; and pharmaceutically acceptable salts thereof, which have utility as therapeutic agents which exhibit anxiolytic, anticonvulsant and muscle relaxant effects in warm blooded animals.
(FR) Nouveaux dérivés d'acide pyrazole-4-acétique correspondant à la formule (I) dans laquelle Y représente hydrogène ou un substituant halogène, alkyle C1-C4 ou alcoxy C1-C4; Z représente un substituant hydroxy, alcoxy C1-C4 ou -NRR; et R représente hydrogène ou un substituant alkyle C1-C4; et leurs sels pharmaceutiquement acceptables. Il présente une utilité comme agent thérapeutique caractérisé par des effets anxiolytiques, anticonvulsivants et relaxants musculaires chez les animaux à sang chaud.
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