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1. WO1992017190 - DRY STARCH-IODINE PHARMACEUTICAL FORMULATIONS

Publication Number WO/1992/017190
Publication Date 15.10.1992
International Application No. PCT/CA1992/000115
International Filing Date 18.03.1992
Chapter 2 Demand Filed 26.10.1992
IPC
A61K 33/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
18Iodine; Compounds thereof
A61K 47/48 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
CPC
A61K 33/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
18Iodine; Compounds thereof
A61K 47/61
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
61the organic macromolecular compound being a polysaccharide or a derivative thereof
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • GHENT, William, R. [CA]/[CA]
  • ESKIN, Bernard, A. [US]/[US]
Inventors
  • GHENT, William, R.
  • ESKIN, Bernard, A.
Agents
  • ERRATT, Judy, A.
Priority Data
676,17028.03.1991US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DRY STARCH-IODINE PHARMACEUTICAL FORMULATIONS
(FR) PREPARATIONS PHARMACEUTIQUES SECHES A BASE D'AMIDON/IODE
Abstract
(EN) The present invention is concerned with the use of starch as a complexant with iodine for preparing dry powder pharmaceutical formulations useful in the prepration of capsules or tablets. The helical structure of the amylose molecule and its ability to complex with iodine make starch (amylose) a desirable carrier for the administration of iodine (I2) as a dry powder formulation in capsule or tablet form. These pharmaceutical formulations are particularly useful in the treatment of or the prevention of iodine deficiency diseases including breast dysplasia, breast cancer, endometriosis, premenstrual syndrome and radiation sickness from nuclear fallout.
(FR) L'invention concerne l'utilisation d'amidon en tant que complexant et combiné avec de l'iode pour la préparation de produits pharmnaceutiques pulvérulents utilisables pour la préparation de capsules ou de comprimés. En raison de la structure hélicoïdale de la molécule amylose et de sa susceptibilité à se lier à l'iode, l'amidon (amylose) s'avère un porteur approprié pour l'administration de l'iode (I2) en tant que préparation pulvérulente sous forme de gélules ou de comprimés. Ces préparations pharmaceutiques sont particulièrement utiles dans le traitement ou la prévention de maladies dues à une déficience d'iode, notamment la dysplasie et le cancer du sein, l'endométriose, le syndrome prémenstruel et le mal des rayons dû à une exposition aux retombées nucléaires
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