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1. WO1992016524 - BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE

Publication Number WO/1992/016524
Publication Date 01.10.1992
International Application No. PCT/US1992/002271
International Filing Date 19.03.1992
Chapter 2 Demand Filed 16.10.1992
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07D 223/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
223Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
14condensed with carbocyclic rings or ring systems
16Benzazepines; Hydrogenated benzazepines
C07D 267/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
267Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
02Seven-membered rings
08having the hetero atoms in positions 1 and 4
12condensed with carbocyclic rings or ring systems
14condensed with one six-membered ring
C07D 279/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
279Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
101,4-Thiazines; Hydrogenated 1,4-thiazines
14condensed with carbocyclic rings or ring systems
16condensed with one six-membered ring
C07D 281/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
281Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
02Seven-membered rings
04having the hetero atoms in positions 1 and 4
08condensed with carbocyclic rings or ring systems
10condensed with one six-membered ring
C07D 401/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 223/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
223Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
14condensed with carbocyclic rings or ring systems
16Benzazepines; Hydrogenated benzazepines
C07D 267/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
267Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
02Seven-membered rings
08having the hetero atoms in positions 1 and 4
12condensed with carbocyclic rings or ring systems
14condensed with one six-membered ring
C07D 279/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
279Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
101,4-Thiazines; Hydrogenated 1,4-thiazines
14condensed with carbocyclic rings or ring systems
16condensed with one six-membered ring
C07D 281/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
281Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
02Seven-membered rings
04having the hetero atoms in positions 1 and 4
08condensed with carbocyclic rings or ring systems
10condensed with one six-membered ring
Applicants
  • MERCK & CO., INC. [US]/[US]
Inventors
  • FISHER, Michael, H.
  • WYVRATT, Matthew, J.
  • SCHOEN, William, R.
  • DeVITA, Robert, J.
Agents
  • ROSE, David, L.
Priority Data
673,69520.03.1991US
839,74228.02.1992US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE
(FR) LACTAME A FUSION BENZO FAVORISANT LA SECRETION DE L'HORMONE DE CROISSANCE
Abstract
(EN)
There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed.
(FR)
L'invention concerne de nouveaux composés identifiés comme étant des lactames à fusion benzo, qui favorisent la sécrétion de l'hormone de croissance chez les hommes et les animaux. Cette propriété peut être utilisée pour stimuler la croissance d'animaux destinés à la production de produits alimentaires, pour rendre la production de produit à base de viande plus efficace, et chez les hommes, pour développer la taille de ceux affligés par un manque de sécrétion normale de l'hormone de croissance naturelle. L'invention concerne également des compositions favorisant la croissance contenant de tels lactames à fusion benzo comme ingrédient actif.
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