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1. WO1992016497 - AMINO ACID DERIVATIVE HAVING RENIN INHIBITORY ACTIVITY

Publication Number WO/1992/016497
Publication Date 01.10.1992
International Application No. PCT/JP1992/000329
International Filing Date 18.03.1992
IPC
C07C 271/16 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
08having oxygen atoms of carbamate groups bound to acyclic carbon atoms
10with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
16to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
C07C 323/60 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
51having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
60with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
C07D 209/30 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
C07D 209/34 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
32Oxygen atoms
34in position 2
C07D 217/26 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
22with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C07D 233/54 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
233Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54having two double bonds between ring members or between ring members and non-ring members
CPC
C07C 2601/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
12with a six-membered ring
14The ring being saturated
C07C 271/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acids, i.e. compounds containing any of the groups , the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
08having oxygen atoms of carbamate groups bound to acyclic carbon atoms
10with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
16to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
C07C 323/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
51having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
60with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
C07D 209/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
C07D 209/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
30with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
32Oxygen atoms
34in position 2
C07D 217/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
22with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Applicants
  • JAPAN TOBACCO INC. [JP]/[JP] (AllExceptUS)
  • YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. [JP]/[JP] (AllExceptUS)
  • SHIBATA, Saizo [JP]/[JP] (UsOnly)
  • YAMADA, Yasuki [JP]/[JP] (UsOnly)
  • TADA, Hiroki [JP]/[JP] (UsOnly)
  • TSUJI, Hiroyuki [JP]/[JP] (UsOnly)
  • UCHIDA, Itsuo [JP]/[JP] (UsOnly)
  • NAKAMURA, Ikuro [JP]/[JP] (UsOnly)
  • HAYASHI, Yoshiharu [JP]/[JP] (UsOnly)
  • IKEGAMI, Kiyoteru [JP]/[JP] (UsOnly)
Inventors
  • SHIBATA, Saizo
  • YAMADA, Yasuki
  • TADA, Hiroki
  • TSUJI, Hiroyuki
  • UCHIDA, Itsuo
  • NAKAMURA, Ikuro
  • HAYASHI, Yoshiharu
  • IKEGAMI, Kiyoteru
Agents
  • TAKASHIMA, Hajime
Priority Data
3/13076922.03.1991JP
3/25689502.07.1991JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) AMINO ACID DERIVATIVE HAVING RENIN INHIBITORY ACTIVITY
(FR) DERIVE D'ACIDE AMINE AYANT UNE ACTIVITE INHIBANT LA RENINE
Abstract
(EN) Compounds represented by general formulae (I), (II) and (III), wherein compound (I) is useful as a renin inhibitor, while compounds (II) and (III) are intermediates for the production thereof.
(FR) Composés représentés par les formules générales (I), (II) et (III) dans lesquels un composé (I) est utilisé comme inhibiteur de rénine, tandis que les composés (II) et (III) constituent des intermédiaires pour sa production.
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