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1. WO1992016496 - N-[[4,5-DIHYDROXY- AND 4,5,8-TRIHYDROXY-9,10-DIHYDRO-9,10-DIOXO-2-ANTHRACENE-YL]CARBONYL]AMINO ACIDS USEFUL IN THE THERAPY OF OSTEOARTICULAR AFFECTIONS

Publication Number WO/1992/016496
Publication Date 01.10.1992
International Application No. PCT/EP1992/000479
International Filing Date 04.03.1992
Chapter 2 Demand Filed 02.10.1992
IPC
C07C 235/84 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
70having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
84with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C07C 323/59 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
51having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
57the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
58with amino groups bound to the carbon skeleton
59with acylated amino groups bound to the carbon skeleton
CPC
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07C 235/84
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
235Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
70having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
84with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C07C 2603/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2603Systems containing at least three condensed rings
02Ortho- or ortho- and peri-condensed systems
04containing three rings
22containing only six-membered rings
24Anthracenes; Hydrogenated anthracenes
C07C 323/59
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
323Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
50containing thio groups and carboxyl groups bound to the same carbon skeleton
51having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
57the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
58with amino groups bound to the carbon skeleton
59with acylated amino groups bound to the carbon skeleton
Applicants
  • ISTITUTO GENTILI S.P.A. [IT]/[IT] (AllExceptUS)
  • ROSINI, Sergio [IT]/[IT] (UsOnly)
  • MIAN, Maurizio [IT]/[IT] (UsOnly)
Inventors
  • ROSINI, Sergio
  • MIAN, Maurizio
Agents
  • BIANCHETTI, Giuseppe
Priority Data
MI91A00065812.03.1991IT
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) N-[[4,5-DIHYDROXY- AND 4,5,8-TRIHYDROXY-9,10-DIHYDRO-9,10-DIOXO-2-ANTHRACENE-YL]CARBONYL]AMINO ACIDS USEFUL IN THE THERAPY OF OSTEOARTICULAR AFFECTIONS
(FR) ACIDES AMINES N-[[4,5-DIHYDROXY- ET 4,5,8-TRIHYDROXY-9,10-DIHYDRO-9,10-DIOXO-2-ANTHRACENE-YL]CARBONYLE] UTILES DANS LA THERAPIE DES PATHOLOGIES OSTEOARTICULAIRES
Abstract
(EN)
N-[[4,5-dihydroxy-9,10-dihydro-9,10-dioxo-2-anthracene-yl]carbonyl] amino acids having anti-inflammatory action, of general formula (I) wherein: X is selected from H and OH; R is a residue which, linked to the group $g(a), forms an amino acid; a process for the preparation thereof and the use thereof in human therapy.
(FR)
Acides aminés N-[[4,5-dihydroxy-9,10-dihydro-9,10-dioxo-2-anthracène-yl]carbonyle] ayant une action anti-inflammatoire, de la formule générale (I) dans laquelle X est choisi entre H et OH, et R est un résidu qui, lié au groupe $g(a), forme un acide aminé, procédé de préparation desdits acides et leur utilisation en thérapie humaine.
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