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1. WO1992015604 - ANTI-TESTOSTERONE COMPOUNDS AND METHOD OF USE THEREOF

Publication Number WO/1992/015604
Publication Date 17.09.1992
International Application No. PCT/US1992/001420
International Filing Date 27.02.1992
Chapter 2 Demand Filed 21.09.1992
IPC
C07J 31/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
31Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
C07J 33/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
33Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopentahydrophenanthrene skeleton
C07J 41/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
C07J 51/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
51Normal steroids with unmodified cyclopentahydrophenanthrene skeleton not provided for in groups C07J1/-C07J43/151
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07J 31/003
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
31Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
003the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
C07J 33/007
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
33Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
005spiro-condensed
007Cyclic thioketals
C07J 41/0005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
41Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
0005the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
C07J 51/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
51Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
Applicants
  • NEW YORK UNIVERSITY [US]/[US]
Inventors
  • WILSON, Stephen, R.
  • MIAO, Emily
Agents
  • BROWDY, Roger, L.
Priority Data
661,16327.02.1991US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-TESTOSTERONE COMPOUNDS AND METHOD OF USE THEREOF
(FR) COMPOSES ANTI-TESTOSTERONE ET METHODE D'UTILISATION DE CES COMPOSES
Abstract
(EN)
Compounds are provided which are highly selective inhibitors of the cytochrome P-450C17, commonly known as 17,20-lyase enzyme, responsible for androgen biosynthesis. These compounds can be administered to patients to inhibit the production of testosterone and estradiol, which is particularly valuable in the clinical treatment of prostate cancer and benign prostatic hyperplasia, as well as of uterine cancer, ovarian cancer and estradio-dependent breast cancer.
(FR)
Composés présentant les caractéristiques d'inhibiteurs hautement sélectifs du cytochrome P-450C17, désignés communément 17,20-lyase enzyme, responsables de la biosynthèse des androgènes. Ces composés peuvent être administrés à des patients afin d'inhiber la production de testostérone et d'estradiol, ce qui est particulièrement appréciable dans le traitement clinique du cancer de la prostate ou de l'hyperplasie prostatique bénigne ainsi que du cancer de l'utérus, du cancer des ovaires et du cancer du sein estradio-dépendant.
Also published as
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