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1. WO1992014733 - PHARMACEUTICALS

Publication Number WO/1992/014733
Publication Date 03.09.1992
International Application No. PCT/GB1992/000310
International Filing Date 20.02.1992
IPC
C07D 451/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
451Heterocyclic compounds containing 8-azabicyclo octane, 9-azabicyclo nonane, or 3-oxa-9-azatricyclo nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02containing not further condensed 8-azabicyclo octane or 3-oxa-9-azatricyclo nonane ring systems, e.g. tropane; Cyclic acetals thereof
04with hetero atoms directly attached in position 3 of the 8-azabicyclo octane or in position 7 of the 3-oxa-9-azatricyclo nonane ring system
C07D 451/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
451Heterocyclic compounds containing 8-azabicyclo octane, 9-azabicyclo nonane, or 3-oxa-9-azatricyclo nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
14containing 9-azabicyclo nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
CPC
C07D 451/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
451Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
04with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
C07D 451/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
451Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
14containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
Applicants
  • SMITHKLINE BEECHAM P.L.C. [GB]/[GB] (AllExceptUS)
  • KING, Francis, David [GB]/[GB] (UsOnly)
  • GASTER, Laramie, Mary [GB]/[GB] (UsOnly)
Inventors
  • KING, Francis, David
  • GASTER, Laramie, Mary
Agents
  • JONES, Pauline
Priority Data
9103839.823.02.1991GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHARMACEUTICALS
(FR) PRODUITS PHARMACEUTIQUES
Abstract
(EN)
Compounds of formula (I) and pharmaceutically acceptable salt thereof, wherein X is a phenyl group or a monocyclic 5 or 6 membered heteroaryl group, either of which group is optionally fused to a saturated or unsaturated 5-7 membered carbocyclic or heterocyclic ring; Y is NCN, NRx or CRx wherein Rx is NO2, CORy or SO2Ry, wherein Ry is C1-3 alkyl, NH2, NH(C1-3 alkyl), CF3 or phenyl optionally substituted by one, two or three groups selected from C1-4 alkyl, C1-4 alkoxy, nitro, halo, CF3 and cyano; and Z is a di-azacyclic or azabicyclic side chain, such as a saturated azabicyclic moiety; are 5-HT3 receptor antagonists.
(FR)
Composés de formule (I) et leurs sels acceptables pharmaceutiquement dans laquelle X représente un groupe phényle ou un groupe monocyclique hétéroaryle à 5 ou 6 éléments, l'un ou l'autre groupe étant éventuellement fusionné avec un noyau hétérocyclique ou carbocyclique à 5-7 éléments, saturé ou insaturé; Y représente NCN, NRx ou CRx, où Rx représente NO2, CORy ou SO2Ry, où Ry représente alkyle C1-3, NH2, NH(alkyle C1-3), CF3 ou phényle éventuellement substitué par un, deux ou trois groupes sélectionnés à partir d'alkyle C1-4, alkoxy C1-4, nitro, halo, CF3 et cyano; et Z représente une chaîne latérale di-azacyclique ou azabicyclique, telle qu'une fraction azabicyclique saturée. Lesdits composés et leurs sels acceptables pharmaceutiquement sont des antagonistes du récepteur de 5-HT3.
Also published as
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