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1. WO1992014732 - INDOLES USEFUL AS PLATELET ACTIVATING FACTOR ANTAGONISTS

Publication Number WO/1992/014732
Publication Date 03.09.1992
International Application No. PCT/US1992/001195
International Filing Date 14.02.1992
Chapter 2 Demand Filed 03.09.1992
IPC
C07D 409/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 417/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
CPC
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
C07D 409/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
14containing three or more hetero rings
Applicants
  • ABBOTT LABORATORIES [US]/[US] (AllExceptUS)
  • SUMMERS, James, B. [US]/[US] (UsOnly)
  • SHEPPARD, George, S. [US]/[US] (UsOnly)
  • PHILLIPS, James, G. [US]/[US] (UsOnly)
  • PIREH, Daisy [IR]/[US] (UsOnly)
  • STEINMAN, Douglas, H. [US]/[US] (UsOnly)
  • MAY, Paul, D. [US]/[US] (UsOnly)
  • GUINN, Denise, E. [US]/[US] (UsOnly)
  • HEYMAN, H., Robin [US]/[US] (UsOnly)
  • CARRERA, George, M., Jr. [US]/[US] (UsOnly)
  • DAVIDSEN, Steven, K. [US]/[US] (UsOnly)
Inventors
  • SUMMERS, James, B.
  • SHEPPARD, George, S.
  • PHILLIPS, James, G.
  • PIREH, Daisy
  • STEINMAN, Douglas, H.
  • MAY, Paul, D.
  • GUINN, Denise, E.
  • HEYMAN, H., Robin
  • CARRERA, George, M., Jr.
  • DAVIDSEN, Steven, K.
Agents
  • GORMAN, Edward, H., Jr.
  • JANSSEN, Jerry, F.
Priority Data
658,13420.02.1991US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INDOLES USEFUL AS PLATELET ACTIVATING FACTOR ANTAGONISTS
(FR) INDOLES UTILES COMME ANTAGONISTES DU FACTEUR D'ACTIVATION DES PLAQUETTES
Abstract
(EN)
Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
(FR)
L'invention se rapporte à des composés d'indole, qui sont substitués aux positions 1 ou 3 par un groupe (pyrid-3-yl)thiazolid-4-yl alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- ou (pyrid-3-yl)dithiolan-4-oyl)- et qui constituent de puissants inhibiteurs du facteur d'activation des plaquettes et sont utiles dans le traitement des troubles associés au facteur d'activation des plaquettes, tels que choc septique, syndrome de la détresse respiratoire, inflammations aiguës, immunité cellulaire retardée, parturition, maturation des poumons du foetus et différenciation cellulaire.
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