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1. (WO1992014452) DELAYED RELEASE ORAL DOSAGE FORMS FOR TREATMENT OF INTESTINAL DISORDERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/014452 International Application No.: PCT/GB1992/000318
Publication Date: 03.09.1992 International Filing Date: 21.02.1992
Chapter 2 Demand Filed: 03.09.1992
IPC:
A61K 9/48 (2006.01) ,A61K 9/50 (2006.01) ,A61K 31/415 (2006.01) ,A61K 31/65 (2006.01) ,A61K 33/24 (2006.01) ,A61K 47/48 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
65
Tetracyclines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
RHODES, John [GB/GB]; GB
EVANS, Brian, Kenneth [GB/GB]; GB
Inventors:
RHODES, John; GB
EVANS, Brian, Kenneth; GB
Agent:
BURFORD, Anthony, Frederick; W.H. Beck, Greener & Co. 7 Stone Buildings Lincoln's Inn London WC2A 3SZ, GB
Priority Data:
9103795.222.02.1991GB
Title (EN) DELAYED RELEASE ORAL DOSAGE FORMS FOR TREATMENT OF INTESTINAL DISORDERS
(FR) FORMES PHARMACEUTIQUES ORALES A LIBERATION PROLONGEE SERVANT AU TRAITEMENT DE TROUBLES INTESTINAUX
Abstract:
(EN) An orally administrable pharmaceutical dosage form for selectively administering a drug to the intestine comprises a plurality of enteric coated granules of the drug contained in an enterically coated capsule which releases the granules in the small intestine. The granules are preferably coated with a coating which remains intact until the coated granules reach at least the ileum and thereafter provide a sustained release of the drug in the colon. Suitable coating materials are selected from the Eudragit range of (meth)acrylate and (meth)acrylic acid polymers. The invention has particular application to topically active drugs such as topically active steroids, bismuth salts and complexes, and especially, 5-amino-salicylic acid.
(FR) Forme pharmaceutique s'administrant oralement et servant à libérer sélectivement un médicament dans l'intestin. Ladite forme pharmaceutique comprend une pluralité de granules à délitage intestinal contenus dans une capsule à délitage intestinal libérant lesdits granules de médicaments dans l'intestin grêle. Les granules sont, de préférence, recouverts d'un revêtement restant intact jusqu'à ce qu'ils arrivent dans l'ilion, au moins, et ils effectuent, ensuite, une libération prolongée du médicament dans le colon. Les matériaux de revêtement adéquates sont sélectionnés à partir de la gamme Eudragit de polymères de méthacrylate et d'acide méthacrylique. L'invention s'applique particulièrement à des médicaments à action locale tels que des stéroïdes à action locale, des sels et des complexes de bismuth et, particulièrement, des acides 5-amino-salicyliques.
Designated States: AU, BB, BG, CA, CS, FI, GB, GE, HU, JP, KP, KR, LK, MW, NO, PL, RO, RU, SD, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CZPV1993-1626FI933680NO19932979EP0572486US5401512JPH06505246
CA2104686KR1019930702963AU1992012795