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1. (WO1992012160) BRIDGED CYCLIC KETAL DERIVATIVES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/012160 International Application No.: PCT/EP1992/000019
Publication Date: 23.07.1992 International Filing Date: 07.01.1992
Chapter 2 Demand Filed: 04.08.1992
IPC:
C07D 493/08 (2006.01) ,C07H 9/04 (2006.01) ,C07H 19/01 (2006.01) ,C12P 17/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
08
Bridged systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
9
Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
02
the hetero ring containing only oxygen as ring hetero atoms
04
Cyclic acetals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
01
sharing oxygen
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
17
Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms
18
containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
Applicants:
GLAXO GROUP LIMITED [GB/GB]; Glaxo House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
SIDEBOTTOM, Philip, James [GB/GB]; GB (UsOnly)
HARTLEY, Charles, David [GB/GB]; GB (UsOnly)
PROCOPIOU, Panayiotis, Alexandrou [GB/GB]; GB (UsOnly)
LESTER, Michael, George [GB/GB]; GB (UsOnly)
WATSON, Nigel, Stephen [GB/GB]; GB (UsOnly)
KIRK, Barrie, Edward [GB/GB]; GB (UsOnly)
COX, Brian [GB/GB]; GB (UsOnly)
ROBERTS, Suzanne, Elaine [GB/GB]; GB (UsOnly)
ROSS, Barry, Clive [GB/GB]; GB (UsOnly)
Inventors:
SIDEBOTTOM, Philip, James; GB
HARTLEY, Charles, David; GB
PROCOPIOU, Panayiotis, Alexandrou; GB
LESTER, Michael, George; GB
WATSON, Nigel, Stephen; GB
KIRK, Barrie, Edward; GB
COX, Brian; GB
ROBERTS, Suzanne, Elaine; GB
ROSS, Barry, Clive; GB
Agent:
BREWER, Christopher, Laurence; Glaxo Holdings plc Glaxo House Berkeley Avenue Greenford Middlesex UB6 0NN, GB
Priority Data:
9100419.209.01.1991GB
9100434.109.01.1991GB
9100435.809.01.1991GB
9100436.609.01.1991GB
9100438.209.01.1991GB
9100439.009.01.1991GB
9100440.809.01.1991GB
9100442.409.01.1991GB
9116613.201.08.1991GB
9116982.107.08.1991GB
Title (EN) BRIDGED CYCLIC KETAL DERIVATIVES
(FR) CETALS CYCLIQUES PONTES
Abstract:
(EN) These compounds inhibit the enzyme squalene synthase and/or are intermediates for the preparation of compounds which inhibit the enzyme squalene synthase. Compounds of the invention may be formulated for use in a variety of conditions where a lowering of the level of blood plasma cholesterol in animals would be beneficial and for use in combating fungal infections in animals.
(FR) Ces composés inhibent la synthase du squalène et/ou sont des intermédiaires pour la préparation de composés inhibant la synthase du squalène. Lesdits composés peuvent s'appliquer à diverses affections contre lesquelles un abaissement de la cholestérolémie chez les animaux serait positif, ainsi qu'à la lutte contre les mycoses chez les animaux.
Designated States: AT, AU, BB, BG, BR, CA, CH, DE, DK, ES, FI, GB, HU, JP, KP, KR, LK, LU, MG, MN, MW, NL, NO, PL, RO, RU, SD, SE, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0568553JPH06504529AU1992011546