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Machine translation
1. (WO1992011866) LAMININ SEQUENCE AS tPA ACTIVATOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1992/011866    International Application No.:    PCT/US1992/000353
Publication Date: 23.07.1992 International Filing Date: 14.01.1992
IPC:
A61K 38/49 (2006.01), A61L 33/12 (2006.01), C07K 14/78 (2006.01)
Applicants: DUKE UNIVERSITY [US/US]; 07 Allen Building, Durham, NC 27710 (US)
Inventors: PIZZO, Salvatore, V.; (US).
STACK, Sharon; (US)
Agent: RAE-VENTER, Barbara; Cooley Godward Castro Huddleson & Tatum, Five Palo Alto Square, 4th Floor, Palo Alto, CA 94306 (US)
Priority Data:
640,616 14.01.1991 US
Title (EN) LAMININ SEQUENCE AS tPA ACTIVATOR
(FR) SEQUENCE DE LAMININE UTILES COMME ACTIVATEUR DE tPA
Abstract: front page image
(EN)A laminin sequence of C-S-R-A-R-K-Q-A-A-S-I-K-V-A-V-S-A-D-R-NH¿2? or analogs thereof are provided for use in conjunction with tPA to greatly enhance plasminogen activation by the tPA. Formulations are provided combining the laminin fragment or analog thereof with tPA or functional analog thereof to be administered at substantially lower levels than required by tPA itself to provide protection against embolisms.
(FR)Une séquence de laminine de C-S-R-A-R-K-Q-A-A-S-I-K-V-A-V-S-A-D-R-NH¿2? ou ses analogues sont utilisés en association avec le tPA pour augmenter considérablement l'activation de plasminogène par le tPA. Des formulations combinent le fragment de laminine ou son analogue avec le tPA ou son analogue fonctionnel pour être administré à des niveaux sensiblement inférieurs à ceux requis par le tPA lui-même tout en assurant une protection contre les embolies.
Designated States: CA, JP, KR.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)