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Machine translation
1. (WO1992011276) NOVEL SYNTHESIS OF 2'-'UP' FLUORINATED 2''-DEOXY-ARABINOFURANOSYLPURINES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1992/011276    International Application No.:    PCT/US1991/009586
Publication Date: 09.07.1992 International Filing Date: 18.12.1991
Chapter 2 Demand Filed:    09.07.1992    
IPC:
C07H 19/16 (2006.01)
Applicants: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH [US/US]; 1275 York Avenue, New York, NY 10021 (US) (For All Designated States Except US).
WATANABE, Kyoichi, A. [JP/US]; (US) (For US Only).
PANKIEWICZ, Krzysztof, W. [US/US]; (US) (For US Only).
KRZEMINSKI, Jacek [PL/US]; (US) (For US Only).
NAWROT, Barbara [PL/PL]; (PL) (For US Only)
Inventors: WATANABE, Kyoichi, A.; (US).
PANKIEWICZ, Krzysztof, W.; (US).
KRZEMINSKI, Jacek; (US).
NAWROT, Barbara; (PL)
Agent: WHITE, John, P.; Cooper & Dunham, 30 Rockefeller Plaza, New York, NY 10112 (US)
Priority Data:
630,275 18.12.1990 US
Title (EN) NOVEL SYNTHESIS OF 2'-'UP' FLUORINATED 2''-DEOXY-ARABINOFURANOSYLPURINES
(FR) NOUVELLE SYNTHESE DE 2''-DESOXYARABINOFURANOSYLPURINES FLUOREES EN POSITION 2'-'UP'
Abstract: front page image
(EN)The present invention provides a compound having structure (I) or (II), wherein R?1¿ is hydrogen, benzyl, or a substituted benzyl group; X is hydrogen, a fluoro, an amino, or a substituted amino group; Y is hydrogen, a methoxy, a methylthio, a benzylthio, an isopropyl, a chloro, an amino, or a substituted amino group; Y' is an oxo or a thio group; and Z is hydrogen, a hydroxy, a methoxy, a halogen, an amino, or a substituted amino group. The present invention also provides processes for synthesizing a compound having the above-identified structure as well as the intermediate compounds produced thereby.
(FR)L'invention se rapporte à un composé ayant la structure (I) ou (II), où R?1¿ représente l'hydrogène, un benzyle ou un groupe benzyle substitué; X représente l'hydrogène, un fluoro, un amino ou un groupe amino substitué; Y représente l'hydrogène, un méthoxy, un méthylthio, un benzylthio, un isopropyle, un chloro, un amino ou un groupe amino substitué; Y' représente un oxo ou un group thio; et Z représente l'hydrogène, un hydroxy, un méthoxy, un halogène, un amino ou un groupe amino substitué. L'invention se rapporte également à des procédés de synthèse d'un composé ayant la structure précitée ainsi qu'à des composés intermédiaires ainsi produits.
Designated States: AU, CA, JP, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)