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Machine translation
1. (WO1992011245) 2-ACYLAMIDO DERIVATIVES OF 3,4-DIHYDRO-3-OXO-QUINOXALINE HAVING PHARMACEUTICAL ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1992/011245    International Application No.:    PCT/US1991/008586
Publication Date: 09.07.1992 International Filing Date: 22.11.1991
Chapter 2 Demand Filed:    30.06.1992    
IPC:
C07C 233/15 (2006.01), C07C 251/38 (2006.01), C07D 241/44 (2006.01), C07D 409/12 (2006.01), C07D 409/14 (2006.01), C07D 413/12 (2006.01)
Applicants: WARNER-LAMBERT COMPANY [US/US]; 2800 Plymouth Road, Ann Arbor, MI 48105 (US) (For All Designated States Except US).
HAYS, Sheryl, Jeanne [US/US]; (US) (For US Only).
JOHNSON, Graham [GB/US]; (US) (For US Only).
LESCOSKY, Leonard, Joseph [US/US]; (US) (For US Only).
MALONE, Thomas, Charles [US/US]; (US) (For US Only).
NOVAK, Perry, Michael [US/US]; (US) (For US Only)
Inventors: HAYS, Sheryl, Jeanne; (US).
JOHNSON, Graham; (US).
LESCOSKY, Leonard, Joseph; (US).
MALONE, Thomas, Charles; (US).
NOVAK, Perry, Michael; (US)
Agent: THIERSTEIN, Joan; Warner-Lambert Company, 2800 Plymouth Road, Ann Arbor, MI 48105 (US).
MANSMANN, Ivo; Gödecke AG, P.O. Box 569, Mooswaldallee 1-9, D-7800 Freiburg (DE)
Priority Data:
631,139 20.12.1990 US
Title (EN) 2-ACYLAMIDO DERIVATIVES OF 3,4-DIHYDRO-3-OXO-QUINOXALINE HAVING PHARMACEUTICAL ACTIVITY
(FR) DERIVES 2-ACYLAMIDO DE 3,4-DIHYDRO-3-OXO-QUINOXALINE POSSEDANT UNE ACTIVITE PHARMACEUTIQUE
Abstract: front page image
(EN)The present invention relates to novel 2-acylamide derivatives of 3,4-dihydro-3-oxo-quinoxaline useful as pharmaceutical agents, to methods for their production, to pharmaceutical compositions and methods of treatment therefor. The compounds of the present invention have activity as excitatory amino acid receptor mediators and, thus, are useful in the treatment of a wide range of neurodegenerative disorders including cerebrovascular disorders such as stroke.
(FR)L'invention se rapporte à de nouveaux dérivés 2-acylamido de 3,4-dihydro-3-oxo-quinoxaline utilisés comme agents pharmaceutiques, à leurs procédés de production, à des compositions pharmaceutiques et à des procédés thérapeutiques les mettant en application. Les composés décrits par l'invention possèdent une activité de médiateurs de récepteurs d'acides aminés excitatoires et, de ce fait, ont une utilité thérapeutique dans le traitement d'un grand nombre de troubles neurodégénératifs, y compris les troubles cérébrovasculaires tels que les attaques.
Designated States: AU, CA, FI, JP, KR, NO, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE).
Publication Language: English (EN)
Filing Language: English (EN)