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1. (WO1992010756) HUMAN PHOSPHOLIPASE ACTIVATING PROTEIN AND METHODS FOR DIAGNOSIS OF RHEUMATOID ARTHRITIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/010756 International Application No.: PCT/US1991/009302
Publication Date: 25.06.1992 International Filing Date: 06.12.1991
Chapter 2 Demand Filed: 02.07.1992
IPC:
A61K 38/00 (2006.01) ,C07K 14/47 (2006.01) ,C07K 16/18 (2006.01) ,C12N 15/11 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
Applicants:
BOMALASKI, John, S. [US/US]; US
CLARK, Mike, A. [US/US]; US
SHORR, Robert, G., L. [US/US]; US
Inventors:
BOMALASKI, John, S.; US
CLARK, Mike, A.; US
SHORR, Robert, G., L.; US
Agent:
ELDERKIN, Dianne, B. ; Woodcock Washburn Kurtz Mackiewicz & Norris One Liberty Place - 46th floor Philadelphia, PA 19103, US
Priority Data:
626,58906.12.1990US
Title (EN) HUMAN PHOSPHOLIPASE ACTIVATING PROTEIN AND METHODS FOR DIAGNOSIS OF RHEUMATOID ARTHRITIS
(FR) PROTEINE D'ACTIVATION DE LA PHOSPHOLIPASE HUMAINE ET PROCEDES POUR DIAGNOSTIQUER LE RHUMASTIME ARTICULAIRE
Abstract:
(EN) The invention provides methods for detecting elevated levels of phospholipase A2, activating protein in persons suspected of having rheumatoid arthritis to thereby indicate the presence of rheumathoid arthritis in the person comprising the steps of providing a sample of body fluid or tissue from said person; contacting the sample with an antibody specific for phospholipase A2, activating protein such that the antibody binds with phospholipase A2, activating protein in the sample; detecting the antibody thereby indicating the presence of phospholipase A2 activating protein, whereby elevated levels of phospholipase A2 activating protein in the sample as compared with levels found in persons not having rheumatoid arthritis indicates the presence of rheumatoid arthritis in the person. Kits and reagents for detecting rheumatoid arthritis are also provided.
(FR) L'invention concerne des procédés de détection de niveaux élevés de la protéine d'activation de phospholipase A2 chez des personnes qui, on suppose, peuvent souffrir de rhumatismes articulaires en vue d'indiquer la présence de rhumatismes articulaires chez la personne et comprenant les étapes suivantes: utilisation d'un échantillon de fluide ou de tissu du corps de ladite personne; mise en contact de l'échantillon avec un anticorps spécifique contre la protéine d'activation de phospholipase A2 de sorte que l'anticorps se lie à la protéine d'activation de la phospholipase A2 dans l'échantillon; détection de l'anticorps indiquant ainsi la présence de la protéine d'activation de la phospholipase A2 de sorte que des niveaux élevés de protéine d'activation de phospholipase A2 dans l'échantillon par rapport à des niveaux trouvés chez des personnes ne souffrant pas de rhumatismes articulaires indiquent la présence de rhumatismes articulaires chez la personne en question. Des kits et des réactifs de détection du rhumatisme articulaire sont également décrits.
Designated States: AU, CA, FI, JP, KR, NO, SU
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP0563244JPH06503647CA2097935AU1991091473