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1. (WO1992010755) PROTEINS WITH CHANGED EPITOPES AND METHODS FOR THE PRODUCTION THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/010755 International Application No.: PCT/DK1991/000382
Publication Date: 25.06.1992 International Filing Date: 05.12.1991
Chapter 2 Demand Filed: 26.06.1992
IPC:
A61K 38/00 (2006.01) ,C07K 14/52 (2006.01) ,C07K 14/575 (2006.01) ,C07K 14/745 (2006.01) ,C11D 3/386 (2006.01) ,C12N 9/54 (2006.01) ,G01N 33/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
745
Blood coagulation or fibrinolysis factors
C CHEMISTRY; METALLURGY
11
ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
D
DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
3
Other compounding ingredients of detergent compositions covered in group C11D1/101
16
Organic compounds
38
Products with no well-defined composition
386
Preparations containing enzymes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
48
acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)
50
Proteinases
52
derived from bacteria
54
bacteria being Bacillus
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
NOVO NORDISK A/S [DK/DK]; Novo Allé DK-2880 Bagsværd, DK (AllExceptUS)
LØVBORG, Uffe [DK/DK]; DK (UsOnly)
Inventors:
LØVBORG, Uffe; DK
Agent:
NOVO NORDISK A/S; Patent Department Novo Allé DK-2880 Bagsvaerd, DK
Priority Data:
90610072.205.12.1990EP
Title (EN) PROTEINS WITH CHANGED EPITOPES AND METHODS FOR THE PRODUCTION THEREOF
(FR) PROTEINES PRESENTANT DES EPITOPES MODIFIES ET PROCEDES DE PREPARATION DE CES PROTEINES
Abstract:
(EN) The invention provides methods for selecting where in the amino acid sequence of a protein to modify in order to obtain protein variants evoking a reduced immunological response, and protein variants subsequently produced. Also compositions containing the variants and their use in especially detergents and in medicine is disclosed.
(FR) L'invention se rapporte à des procédés permettant de choisir l'endroit où une modification doit être effectuée dans la séquence d'acides aminés d'une protéine afin que l'on obtienne des variantes de protéines provoquant une réponse immunologique réduite, ainsi qu'à des variantes de protéines produites ultérieurement. On décrit aussi des compositions contenant ces variantes et leur utilisation, plus particulièrement en médecine et dans des détergents.
Designated States: AU, BG, BR, CA, CS, FI, HU, JP, KP, KR, NO, PL, RO, SU, US
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
FI932561EP0561907US5766898US20050209121US6967080JP3355186
JPH06502994JP2002101880 JP2003174871 CA2331936CA2095852DE000069130113
KR1019930703610AU1991090528DK0561907