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1. (WO1992010574) INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS BY AN ADENO-ASSOCIATED VIRUS GENE FOR HUMAN CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/1992/010574 International Application No.: PCT/US1991/009008
Publication Date: 25.06.1992 International Filing Date: 06.12.1991
Chapter 2 Demand Filed: 06.12.1991
IPC:
A61K 38/00 (2006.01) ,C07K 14/015 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
01
DNA viruses
015
Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
Applicants:
THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, U.S. DEPARTMENT OF COMMERCE [US/US]; 5285 Port Royal Road Springfield, VA 22161, US
Inventors:
CARTER, Barrie, J.; US
ANTONI, Beth, Ann; US
RABSON, Arnold, B.; US
MILLER, Irving, L.; US
TREMPE, James, P.; US
CHEJANOVSKY, Nor; IL
Agent:
HOLMAN, John, Clarke ; Fleit, Jacobson, Cohn, Price, Holman & Stern The Jenifer Building 400 Seventh Street, N.W. Washington, DC 20004, US
Priority Data:
623,82606.12.1990US
Title (EN) INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS BY AN ADENO-ASSOCIATED VIRUS GENE FOR HUMAN CELLS
(FR) INHIBITION DU VIRUS DE L'IMMUNODEFICIENCE HUMAINE A L'AIDE D'UN GENE VIRAL A ASSOCIATION ADENO DES CELLULES HUMAINES
Abstract:
(EN) A recombinant plasmid is disclosed according to the invention which comprises a transcription promoter inducible by gene products expressed by a human lentivirus and a gene which is non-homologous to that human lentivirus. The non-homologous gene encodes a gene product which inhibits lentiviral growth and lentiviral protein production by interfering with the $i(trans)-acting gene regulation system of the lentivirus. The expression of the non-homologous gene is further increased by the above-mentioned transcription promoter. The invention further comprises a method of inhibiting lentiviral growth and lentiviral protein production in mammals by transfecting cells of mammals infected with the lentivirus with the above-mentioned recombinant plasmid. The invention further comprises a method of inhibiting lentiviral growth and production by administering to mammals infected with the lentivirus the Rep protein encoded by the above-mentioned non-homologous gene in a pharmaceutically acceptable carrier.
(FR) Plasmide recombiné comportant un promoteur de transcription apte à être induit par des produits génétiques exprimés par un lentivirus humain et par un gène non homologue de celui-ci. Le gène non homologue code un produit génétique qui inhibe la croissance lentivirale et la production de protéines lentivirales en parasitant l'action $i(trans) du système de régulation génique du lentivirus. Ledit promoteur de transcription accroît davantage l'expression du gène non homologue. On a également prévu un procédé d'inhibition chez les mammifères de la croissance lentivirale et de la production de protéines lentivirales, comprenant la transfection avec ledit plasmide recombiné de cellules prélevées sur des mammifères infectés par le lentivirus, ainsi qu'un procédé d'inhibition de la croissance et de la production lentivirales, comprenant l'administration à des mammifères infectés par le lentivirus de la protéine Rep codée par ledit gène non homologue dans un excipient pharmaceutiquement acceptable.
Designated States: AU, CA, JP
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, MC, NL, SE)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU1992011507